Titre :

Tenecteplase in acute ischemic stroke: Review of the literature and expert consensus from the French Neurovascular Society

Auteur(s) :

Olindo, Stéphane [Auteur]
Hôpital Pellegrin
Albucher, Jean-François [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Bejot, Yannick [Auteur]
CHU Dijon
Berge, Jérôme [Auteur]
Hôpital Pellegrin
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Guillon, Benoît [Auteur]
Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
Sablot, Denis [Auteur]
Centre Hospitalier Saint Jean de Perpignan
Tardy, Jean [Auteur]
Clinique des cèdres - Ramsay Santé
Alamowitch, Sonia [Auteur]
CHU Saint-Antoine [AP-HP]
Sibon, Igor [Auteur]
Hôpital Pellegrin

Titre de la revue :

Revue Neurologique

Nom court de la revue :

Rev Neurol (Paris)

Numéro :

179

Pagination :

150-160

Éditeur :

Elsevier Masson

Date de publication :

2022-11-08

ISSN :

0035-3787

Mot(s)-clé(s) en anglais :

Acute ischemic stroke
Tenecteplase
Alteplase
Reperfusion
Expert consensus

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Intravenous alteplase is the only thrombolytic treatment approved for patients with acute ischemic stroke (AIS). Although no randomized controlled trial (RCT) has shown the superiority of tenecteplase over ...
Lire la suite >Background Intravenous alteplase is the only thrombolytic treatment approved for patients with acute ischemic stroke (AIS). Although no randomized controlled trial (RCT) has shown the superiority of tenecteplase over alteplase in AIS, tenecteplase is increasingly used off-label in Stroke Units. The purpose of the present work was to provide an up-to-date set of expert consensus statements on the use of tenecteplase in AIS. Methods Members of the working group were selected by the French Neurovascular Society. RCTs comparing tenecteplase and alteplase in the treatment of AIS were reviewed. Recent meta-analysis and real-life experience data on tenecteplase published until 30th October 2021 were also analyzed. After a description of the available data, we tried to answer the subsequent questions about the use of tenecteplase in AIS: What dosage of tenecteplase should be preferred? How effective is tenecteplase for cerebral artery recanalization? What is the clinical effectiveness of tenecteplase? What is the therapeutic safety of tenecteplase? What are the benefits associated with tenecteplase ease of use? Then expert consensus statements for tenecteplase use were submitted. In October 2021 the working group was asked to review and revise the manuscript. In November 2021, the current version of the manuscript was approved. Expert consensus A set of three expert consensus statements for the use of tenecteplase within 4.5 hours of symptom onset in AIS patients were issued: (1) It is reasonable to use tenecteplase 0.25 mg/kg when mechanical thrombectomy (MT) is planned. (2) Tenecteplase 0.25 mg/kg can be used as an alternative to alteplase 0.9 mg/kg in patients with medium- or small-vessel occlusion not retrievable with MT. (3) Tenecteplase 0.25 mg/kg could be considered as an alternative to alteplase 0.9 mg/kg in patients without vessel occlusion. Conclusions These expert consensus statements could provide a framework to guide the clinical decision-making process for the use of tenecteplase according to admission characteristics of AIS patients. However, existing data are limited, requiring inclusions in ongoing RCTs or real-life registries.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2024-01-16T00:23:37Z
2025-02-21T13:22:57Z