Titre :

Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy.

Auteur(s) :

Forestier, G. [Auteur]
CHU Limoges
Agbonon, R. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bricout, N. [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benhassen, W. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Turc, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bretzner, Martin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benzakoun, J. [Auteur]
Seners, P. [Auteur]
Personnic, Thomas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Legrand, L. [Auteur]
Trystram, D. [Auteur]
Rodriguez-Regent, C. [Auteur]
Charidimou, A. [Auteur]
Rost, N. S. [Auteur]
Bracard, S. [Auteur]
Clarençon, F. [Auteur]
Eker, O. F. [Auteur]
Nighoghossian, N. [Auteur]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Oppenheim, C. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Naggara, O. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Boulouis, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]

Titre de la revue :

Journal of Neurology

Nom court de la revue :

J Neurol

Numéro :

269

Pagination :

4708–4716

Éditeur :

Springer Verlag

Date de publication :

2022-04-08

ISSN :

1432-1459

Mot(s)-clé(s) :

Thrombectomy
Stroke
Cerebral small vessel disease
Collateral circulation
Magnetic resonance imaging

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background and purpose To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic ...
Lire la suite >Background and purpose To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic stroke (AIS). Methods Patients with AIS due to large vessel occlusion (LVO) from the Thrombectomie des Artères Cérébrales (THRACE) trial and prospective cohorts from 2 academic comprehensive stroke centers treated with MT were pooled and retrospectively analyzed. Collaterals’ adequacy was assessed using the American Society of Interventional and Therapeutic Radiology/Society of Interventional Radiology (ASITN/SIR) score on initial digital subtraction angiography and dichotomized as good (3,4) versus poor (0–2) collaterals. The SVD burden was rated with the global SVD score on MRI. Multivariable logistic regression analyses were used to determine relationships between SVD and ASITN/SIR scores. Results A total of 312 participants were included (53.2% males, mean age 67.8 ± 14.9 years). Two hundred and seven patients had poor collaterals (66.4%), and 133 (42.6%) presented with any SVD signature. In multivariable analysis, patients demonstrated worse leptomeningeal collaterality with increasing SVD burden before and after adjustment for SVD risk factors (adjusted odds ratio [aOR] 0.69; 95%CI [0.52–0.89] and aOR 0.66; 95%CI [0.5–0.88], respectively). Using individual SVD markers, poor collaterals were significantly associated with the presence of lacunes (aOR 0.40, 95% CI [0.20–0.79]). Conclusion Our study provides evidence that in patients with AIS due to LVO treated with MT, the burden of SVD assessed by pre-treatment MRI is associated with poorer recruitment of leptomeningeal collaterals.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-16T01:18:46Z
2024-10-23T09:35:50Z