Titre :

Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the real-world FACE-TRD national cohort.

Auteur(s) :

Korchia, Théo [Auteur]
Aix Marseille Université [AMU]
Faugere, Mélanie [Auteur]
Aix Marseille Université [AMU]
Suc, Nicolas [Auteur]
Université de Toulouse [UT]
Garosi, Alexandra [Auteur]
Aix Marseille Université [AMU]
Andrieu-Haller, Christelle [Auteur]
Aix Marseille Université [AMU]
Breyton, Martin [Auteur]
Aix Marseille Université [AMU]
Godin, Ophélia [Auteur]
Aouizerate, Bruno [Auteur]
Université de Bordeaux [UB]
Arbus, Christophe [Auteur]
Université de Toulouse [UT]
Bennabi, Djamila [Auteur]
Université Bourgogne Franche-Comté [COMUE] [UBFC]
Bellivierid, Frank [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Bougerol, Thierry [Auteur]
Université Grenoble Alpes [UGA]
Camus, Vincent [Auteur]
Université de Tours [UT]
Courtet, Philippe [Auteur]
Université de Montpellier [UM]
Doumy, Olivier [Auteur]
Université de Bordeaux [UB]
El-Hage, Wissam [Auteur]
Université de Tours [UT]
Genty, Jean-Baptiste [Auteur]
Université Paris-Est [UPE]
Haffen, Emmanuel [Auteur]
Université Bourgogne Franche-Comté [COMUE] [UBFC]
Holtzmann, Jérome [Auteur]
Université Grenoble Alpes [UGA]
Horn, Mathilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Leboyer, Marion [Auteur]
Université de Bordeaux [UB]
Llorca, Pierre-Michel [Auteur]
Université Clermont Auvergne [UCA]
Maruani, Julia [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Moirand, Rémi [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Moliere, Fanny [Auteur]
Université de Montpellier [UM]
Petrucci, Jean [Auteur]
Université Paris-Est [UPE]
Rey, Romain [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Samalin, Ludovic [Auteur]
Université Clermont Auvergne [UCA]
Stephan, Florian [Auteur]
Vaiva, Guillaume [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Walter, Michel [Auteur]
Yrondid, Antoine [Auteur]
Université de Toulouse [UT]
Boyers, Laurent [Auteur]
Aix Marseille Université [AMU]
Lancon, Christophe [Auteur]
Aix Marseille Université [AMU]
Richieri, Raphaelle [Auteur]
Aix Marseille Université [AMU]
Fond, Guillaume [Auteur]
Aix Marseille Université [AMU]

Titre de la revue :

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Numéro :

114

Pagination :

110479

Date de publication :

2022-03-02

ISSN :

1878-4216

Mot(s)-clé(s) :

public health
psychiatry
depression
tobacco
mental health
public mental health
schizophrenia
smoking

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant ...
Lire la suite >Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant Depression (TRD) according to sex in a precision-medicine approach. Method The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at 6 months. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at 6 months on their smoking and psychiatric hospitalization outcomes. Results 355 TRD participants were included (222 women). The smoking rate was much higher in TRD women compared to the French general population (34% vs 24%) while it was comparable for men (approximately 29%). In multivariate analyses, compared to non-smoking women, female smokers had significantly increased number of lifetime psychiatric hospitalizations (standardized beta B = 0.232, p = 0.014) and electro-convulsive therapy (adjusted odds ratio (aOR) = 2.748, p = 0.005), increased suicidal ideations (aOR = 4.047, p = 0.031), history of suicide attempt (aOR = 1.994, p = 0.033), and increased impulsivity (B = 0.210, p = 0.006) and were more frequently treated by benzodiazepines (aOR = 1.848, p = 0.035) and third- or fourth-line TRD treatments (antipsychotics aOR = 2.270, p = 0.006, mood stabilizers aOR = 2.067 p = 0.044). Tobacco smoking at baseline was predictive of psychiatric hospitalization within 6 months in persistent smoking women (aOR = 2.636, p = 0.031). These results were not replicated in men, for whom tobacco smoking was only associated with increased clinician-rated and self-reported depressive symptoms (respectively B = 0.207, p = 0.022 and B = 0.184, p = 0.048). The smoking cessation rate at 6 months was higher in women than in men (12% vs. 7%). No patient was administered nicotine substitute or varenicline at the two timepoints. Interpretation Combining these results and those of the literature, we recommend that active tobacco cessation should be promoted in TRD to improve depression, suicide and impulsivity especially in women. Female smokers appear as a specific population with heavier mental health outcomes that should be specifically addressed.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-16T01:39:49Z
2024-11-28T10:57:17Z