Title :

Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

Author(s) :

Verhoeven, J. I. [Auteur]
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Casolla, Barbara [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
De Leeuw, F. E. [Auteur]
Leys, Didier [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Klijn, C. J. M. [Auteur]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

European Stroke Journal

Volume number :

6

Pages :

185-193

Publisher :

SAGE Publications

Publication date :

2021-07-03

ISSN :

2396-9873

Keyword(s) :

Intracerebral haemorrhage
young adults
long-term mortality

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ...
Show more >Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors. Patients and methods We included consecutive patients aged 18–55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004–2009), who survived at least 30 days after spontaneous ICH. We studied long-term mortality with Kaplan-Meier analyses, collected causes of death, performed uni-/multivariable Cox-regression analyses for the association of baseline characteristics with long-term mortality. Results Of 560 patients enrolled in the PITCH, 75 patients (75% men) met our inclusion criteria (median age 50 years, interquartile range [IQR] 44–53 years). During a median follow-up of 8.2 years (IQR 5.0–10.1), 26 patients died (35%), with a standardized mortality ratio of 13.0 (95% confidence interval [95% CI] 8.5–18.0) compared to peers from the general population. Causes of death were vascular in 7 (27%) patients, non-vascular in 13 (50%) and unknown in 6 (23%). Global cerebral atrophy (hazard ratio [HR] 3.0, 95% CI 1.1–8.6), modified Rankin Score >2 before ICH (HR 3.4, 95% CI 1.0–11.0), and excessive alcohol consumption (HR 3.3, 95% CI 1.1–10.2) were independently associated with long-term mortality. Discussion We found a 13-fold higher mortality risk for young ICH survivors compared to the general French population. Predictors of long-term mortality were pre-existing conditions, not ICH-characteristics. Conclusion Young ICH survivors remain at increased mortality risk of vascular and non-vascular death for years after ICH.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-16T01:52:01Z
2024-09-18T06:15:04Z