Corpus callosum damage to account for ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?
Author(s) :
Degraeve, Béatrice [Auteur]
Sequeira, Henrique [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Mecheri, Halima [Auteur]
Lenne, Bruno [Auteur]
Sequeira, Henrique [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Mecheri, Halima [Auteur]
Lenne, Bruno [Auteur]
Journal title :
Multiple Sclerosis Journal
Abbreviated title :
Mult Scler
Volume number :
29
Pages :
160-168
Publisher :
SAGE Publications
Publication date :
2022-04-27
HAL domain(s) :
Sciences cognitives
English abstract : [en]
The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages ...
Show more >The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS. For this purpose, we will first review structural and functional evidence of callosal pathology in MS. Second, we will account for the potential role of CC abnormalities in MS-related dysfunctions. Finally, we will report data concurring with a “multiple disconnection hypothesis” that has been proposed to explain those dysfunctions, and we will examine evidence pointing toward MS as a “callosal disconnection syndrome.” We will end by discussing the contribution of this interpretation to the understanding of MS and MS-related deficits.Show less >
Show more >The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS. For this purpose, we will first review structural and functional evidence of callosal pathology in MS. Second, we will account for the potential role of CC abnormalities in MS-related dysfunctions. Finally, we will report data concurring with a “multiple disconnection hypothesis” that has been proposed to explain those dysfunctions, and we will examine evidence pointing toward MS as a “callosal disconnection syndrome.” We will end by discussing the contribution of this interpretation to the understanding of MS and MS-related deficits.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Submission date :
2024-01-17T14:27:14Z