Title :

Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?

Author(s) :

Betka, Sophie [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Brighton and Sussex Medical School [BSMS]
Gould Van Praag, Cassandra [Auteur]
Paloyelis, Yannis [Auteur]
Bond, Rod [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]

Journal title :

Social Cognitive and Affective Neuroscience

Volume number :

13

Pages :

p.440-448

Publisher :

Oxford University Press (OUP)

Publication date :

2018-03-28

English keyword(s) :

alcohol
addiction
alcohol use
oxytocin
interoception
attention

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission ...
Show more >Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission of bodily signals and, through its potential modulation of craving, is proposed as a possible treatment for alcohol use disorders. However, oxytocin’s impact on interoception in alcohol users remains unknown. Healthy alcohol users (n = 32) attended two laboratory sessions to perform tests of interoceptive ability (heartbeat tracking: attending to internal signals and, heartbeat discrimination: integrating internal and external signals) after intranasal administration of oxytocin or placebo. Effects of interoceptive accuracy, oxytocin administration and alcohol intake, were tested using mixed-effects models. On the tracking task, oxytocin reduced interoceptive accuracy, but did not interact with alcohol consumption. On the discrimination task, we found an interaction between oxytocin administration and alcohol intake: Oxytocin, compared with placebo, increased interoceptive accuracy in heavy drinkers, but not in light social drinkers. Our study does not suggest a pure interoceptive impairment in alcohol users but instead potentially highlights reduced flexibility of internal and external attentional resource allocation. Importantly, this impairment seems to be mitigated by oxytocin. This attentional hypothesis needs to be explicitly tested in future research.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Dynamique Émotionnelle et Pathologies (DEEP)

Submission date :

2024-01-17T14:46:12Z
2024-02-12T13:53:26Z
2024-02-16T07:24:31Z