Human Endogenous Retroviruses and Type 1 Diabetes.

Levet, Sandrine; Charvet, B.; Bertin, Antoine; Deschaumes, Arthur; Perron, H.; Hober, Didier

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s11892-019-1256-9

PMID :

31754894

Permalink :

http://hdl.handle.net/20.500.12210/102854

Title :

Human Endogenous Retroviruses and Type 1 Diabetes.

Author(s) :

Levet, Sandrine [Auteur]
Charvet, B. [Auteur]
Bertin, Antoine [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Deschaumes, Arthur [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Perron, H. [Auteur]
Hober, Didier [Auteur]

Laboratoire de virologie - ULR 3610

Journal title :

Current Diabetes Reports

Abbreviated title :

Curr. Diab. Rep.

Volume number :

Pages :

141

Publication date :

2019-11-23

ISSN :

1539-0829

English keyword(s) :

Endogenous retrovirus
Type 1 diabetes
HERV
Enterovirus
Coxsackievirus B4

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose of the Review The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression. Recent Findings The envelope ...
Show more >Purpose of the Review The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression. Recent Findings The envelope protein of HERV-W family, named HERV-W-Env, was detected in pancreata from T1D patients and was shown to display pro-inflammatory properties and direct toxicity toward pancreatic beta cells. Summary The etiopathogenesis of T1D remains elusive, even if conventional environmental viral infections have been recurrently involved. Nonetheless, a new category of pathogens may provide the missing link between genetic susceptibility and environmental factors long thought to contribute to T1D onset. A number of studies have now shown that HERV sequences, which are normally inactivated or repressed in the human genome, could be activated by environmental viruses. Thus, if similarly activated by viruses associated with T1D, disregarded HERV genes may underlie T1D genetic susceptibility. Moreover, once expressed, HERV elements may display broad pathogenic properties, which identify them as potential new therapeutic targets.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:25:50Z
2024-02-08T14:41:55Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/102854*	2024-02-08T14:36:37Z
1	20.500.12210/102854.1	2024-01-17T22:25:50Z

Human Endogenous Retroviruses and Type 1 Diabetes.

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Human Endogenous Retroviruses and Type 1 Diabetes.

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