Does control of glycemia regulate immunological ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes?
Author(s) :
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de virologie - ULR 3610
Fachinan, Rufine [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Fagninou, Adnette [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Moutairou, Kabirou [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Yessoufou, Akadiri [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Laboratoire de virologie - ULR 3610
Fachinan, Rufine [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Fagninou, Adnette [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Alidjinou, Enagnon Kazali [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de virologie - ULR 3610
Moutairou, Kabirou [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Hober, Didier [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de virologie - ULR 3610
Yessoufou, Akadiri [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Journal title :
Diabetes Research and Clinical Practice
Abbreviated title :
Diabetes Res. Clin. Pract.
Volume number :
157
Pages :
107868
Publication date :
2019-10-05
ISSN :
1872-8227
English keyword(s) :
Type 1 diabetes
Glycemic control
Insulin
Immune cells
Cytokines
Glycemic control
Insulin
Immune cells
Cytokines
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
English abstract : [en]
Aims
We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes ...
Show more >Aims We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes (T1D). Methods Clinical data and blood samples were collected from two groups of persons with T1D exhibiting either adequate (AGC) or inadequate glycemic control (IGC), as well as from individuals without diabetes considered as a control group. Serum cytokine levels and immune cell subpopulation frequencies were determined. Results Irrespective of their capacity to control glycemia, the percentages of effector CD4+ T-cells and CD19+ B-cells were higher in persons with T1D than in controls, whilst monocytes were significantly more frequent in those with IGC than in controls. The overall frequencies of CD4+ T-cells, CD8+ T-cells and Foxp3+CD4+CD25+ regulatory T-cells did not differ between the three groups. The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. The level of IL-10 was significantly lower in those with AGC compared to controls. Conclusion Our study shows that insulin treatment is associated with a Th2-biased systemic immune phenotype in persons with T1D, reflected by a high proportion of effector CD4+ T cells and CD19+ B cells and a down-regulation of Th1-type serum cytokines.Show less >
Show more >Aims We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes (T1D). Methods Clinical data and blood samples were collected from two groups of persons with T1D exhibiting either adequate (AGC) or inadequate glycemic control (IGC), as well as from individuals without diabetes considered as a control group. Serum cytokine levels and immune cell subpopulation frequencies were determined. Results Irrespective of their capacity to control glycemia, the percentages of effector CD4+ T-cells and CD19+ B-cells were higher in persons with T1D than in controls, whilst monocytes were significantly more frequent in those with IGC than in controls. The overall frequencies of CD4+ T-cells, CD8+ T-cells and Foxp3+CD4+CD25+ regulatory T-cells did not differ between the three groups. The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. The level of IL-10 was significantly lower in those with AGC compared to controls. Conclusion Our study shows that insulin treatment is associated with a Th2-biased systemic immune phenotype in persons with T1D, reflected by a high proportion of effector CD4+ T cells and CD19+ B cells and a down-regulation of Th1-type serum cytokines.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2024-01-17T22:31:05Z
2024-02-13T10:43:05Z
2024-02-13T10:43:05Z