Titre :

Proteinuria reduction with SGLT2 inhibitors in a patient treated with tyrosine kinase inhibitor lenvatinib.

Auteur(s) :

Fages, Victor [Auteur]
Hôpital Claude Huriez [Lille]
Jannin, Arnaud [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Maanaoui, Mehdi [Auteur]
Hôpital Claude Huriez [Lille]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Do Cao, Christine [Auteur]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]

Titre de la revue :

J Nephrol

Nom court de la revue :

J Nephrol

Date de publication :

2023-07-07

ISSN :

1724-6059

Mot(s)-clé(s) en anglais :

Proteinuria
Tyrosine kinase inhibitors
SGLT2 inhibitors
Lenvatinib

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

We describe the case of a 66-year-old woman treated with tyrosine kinase inhibitor Lenvatinib for thyroid carcinoma who had persistent proteinuria above 2 g/24 h despite maximal dose of angiotensin-converting enzyme ...
Lire la suite >We describe the case of a 66-year-old woman treated with tyrosine kinase inhibitor Lenvatinib for thyroid carcinoma who had persistent proteinuria above 2 g/24 h despite maximal dose of angiotensin-converting enzyme inhibitor. We initiated a treatment with SGLT2 inhibitor Dapagliflozin. Three months after Dapagliflozin initiation, her proteinuria decreased to 1 g/24 h, and after 6 months of follow-up was 0.6 g/24 h. To our knowledge, this is the first case of successful proteinuria reduction with SGLT2i in a patient treated with Lenvatinib. Specific renal effects of SGLT2i seem promising and their effects on tyrosine kinase inhibitor renal adverse effects need to be validated in clinical trials involving cancer patients.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Date de dépôt :

2024-01-19T22:19:26Z
2024-09-18T06:46:56Z