Title :

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Author(s) :

Rovira, M. [Auteur]
Atla, G. [Auteur]
Maestro, M. A. [Auteur]
Grau, V. [Auteur]
García-Hurtado, J. [Auteur]
Maqueda, M. [Auteur]
Mosquera, J. L. [Auteur]
Yamada, Y. [Auteur]
Pattou Kerr-Conte, Julie [Auteur]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Recherche translationnelle sur le diabète (RTD) - U1190
Pattou, Francois [Auteur]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Recherche translationnelle sur le diabète (RTD) - U1190
Ferrer, J. [Auteur]

Journal title :

Genes and Development

Abbreviated title :

Genes Dev

Volume number :

35

Pages :

p. 1229-1242

Publication date :

2021-08-12

ISSN :

1549-5477

English keyword(s) :

REST
beta cells
bipotent progenitors
endocrine differentiation
pancreas
pancreas development
transcriptional repressors

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST ...
Show more >Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in the embryonic pancreas. However, pancreatic Rest knockout mice failed to show abnormal numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we observed a marked increase in pancreatic endocrine cell formation. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts and induced β-cell-specific genes in human adult duct-derived organoids. We also defined genomic sites that are bound and repressed by REST in the embryonic pancreas. Our findings show that REST-dependent inhibition ensures a balanced production of endocrine cells from embryonic pancreatic progenitors.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-19T22:52:10Z
2024-10-02T16:42:55Z