Title :

Risk stratification of adrenal masses by [18F]FDG PET/CT: Changing tactics

Author(s) :

Salgues, Betty [Auteur]
Guerin, Carole [Auteur]
Amodru, Vincent [Auteur]
Pattou, Francois [Auteur]
Service de chirurgie générale et endocrinienne
Recherche translationnelle sur le diabète (RTD) - U1190
Brunaud, Laurent [Auteur]
Lifante, Jean-Christophe [Auteur]
Mirallié, Eric [Auteur]
Shahakian, Nicolas [Auteur]
Castinetti, Frédéric [Auteur]
Loundou, Anderson [Auteur]
Baumstarck, Karine [Auteur]
Sebag, Fréderic [Auteur]
Taïeb, David [Auteur]

Journal title :

Clinical Endocrinology

Abbreviated title :

Clin. Endocrinol. (Oxf)

Volume number :

94

Pages :

133-140

Publisher :

Wiley

Publication date :

2020-09-25

ISSN :

1365-2265

English keyword(s) :

[F-18]FDG
adrenal
adrenocortical carcinoma
computed tomography
incidentaloma

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Context [18F]FDG PET/CT improves adrenal tumour characterization. However, there is still no consensus regarding the optimal imaging biomarkers of malignancy. Objectives To assess the performance of Tumour standardized ...
Show more >Context [18F]FDG PET/CT improves adrenal tumour characterization. However, there is still no consensus regarding the optimal imaging biomarkers of malignancy. Objectives To assess the performance of Tumour standardized uptake value (SUV)max:Liver SUVmax for malignancy-risk and to build and evaluate a prediction model. Design/Methods The cohort consisted of consecutive patients with adrenal masses evaluated by [18F]FDG PET/CT. The gold standard for malignancy was based on histology or a multidisciplinary consensus in nonoperated cases. The performance of the previously reported cut-off for Tumour SUVmax:Liver SUVmax (>1.5) was evaluated in this independent cohort. Additionally, a predictive model of malignancy was built from the training cohort (previous study) and evaluated in the validation cohort (current study). Results Sixty-four patients were evaluated; 28% of them had a Cushing's syndrome. Fifty-four adrenal masses were classified as benign and 10 as malignant (including 7 adrenocortical carcinomas). Compared to benign masses, malignant lesions were larger in size, had higher unenhanced densities and higher [18F]FDG uptake. CT-derived anthropometric parameters did not differ between benign and malignant masses. A tumour SUVmax:Liver SUVmax > 1.5 showed a good diagnostic performance: Se = 90.0%/Sp = 92.6%/PPV = 69.2%/NPV = 98.0% and accuracy = 92.2%. A predictive model based on tumour size and tumour-to-liver uptake SUVmax ratio for malignancy-risk was validated and provides a complementary approach to the ratio. Conclusions Tumour SUVmax:Liver SUVmax uptake ratio is a useful biomarker for diagnosis of adrenal masses. Another tactic would be to calculate with the model an individual risk of malignancy and integrate this information into a shared decision-making process.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-19T23:21:47Z
2024-10-04T13:55:52Z