Titre :

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands

Auteur(s) :

Sansook, Supojjanee [Auteur]
Tuo, Wei [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bollier, Melanie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Barczyk, Amélie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dezitter, Xavier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Klupsch, Frederique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Chavain, Natascha [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Farce, Amaury [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Tizzard, Graham J. [Auteur]
Coles, Simon J. [Auteur]
Spencer, John [Auteur]
Millet, Régis [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Titre de la revue :

Future Medicinal Chemistry

Nom court de la revue :

Future Med Chem

Numéro :

10

Date de publication :

2018-03

ISSN :

1756-8927

Mot(s)-clé(s) en anglais :

isoxazole
cannabinoids
FAAH
ferrocene

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Ferrocene analogs of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bio-organometallic isoxazoles were assayed ...
Lire la suite >Ferrocene analogs of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bio-organometallic isoxazoles were assayed for their effects on CB1 and CB2 receptors as well as on fatty acid amide hydrolase. None had any fatty acid amide hydrolase activity but compound 3, 5-(2-(pentyloxy)phenyl)-N-ferrocenylisoxazole-3-carboxamide, was found to be a potent CB2 ligand (Ki = 32.5 nM).Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-30T10:27:24Z
2024-03-18T13:38:36Z