Title :

Evaluating the prognostic potential of the ki67 index and tumor infiltrating lymphocytes in olfactory neuroblastoma

Author(s) :

Classe, Marion [Auteur]
Institut Gustave Roussy [IGR]
Burgess, Alice [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
El Zein, Sophie [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Wassef, Michel [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Herman, Philippe [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Leroy, Xavier [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Malouf, Gabriel G. [Auteur]
Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC]
Verillaud, Benjamin [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]

Journal title :

Histopathology

Abbreviated title :

Histopathology

Volume number :

75

Pages :

853-864

Publication date :

2019-12

ISSN :

1365-2559

English keyword(s) :

Ki67
tumour-infiltrating lymphocytes
olfactory neuroblastoma
aesthesioneuroblastoma

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, the Hyams grade remains the only widely used histological grading system. However, it is based only on morphological ...
Show more >OBJECTIVE: Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, the Hyams grade remains the only widely used histological grading system. However, it is based only on morphological criteria, and has not been updated since 1988. The objective of this study was to explore the prognostic potential of the Ki67 proliferation index (PI) and tumour-infiltrating lymphocytes (TILs) in ONB. RESULTS: A retrospective study was conducted on a bicentric series of 45 cases. The Ki67 PI was determined by counting at least 1000 nuclei on whole slides. TILs were evaluated with CD20, CD4 and CD8 immunohistochemical markers on whole slides. In this series, Hyams grades I, II, III and IV accounted for 13.4%, 44.4%, 20% and 22.2% of all cases, respectively. The Ki67 PI ranged from 1 to 93; the Ki67 PI was significantly higher in Hyams grade III-IV ONBs than in Hyams grade I-II ONBs (P < 0.0001). A Ki67 PI of ≥25 was associated with poorer survival (P = 0.02). TILs were present in both stromal and intratumoral compartments, but were located predominantly in the stromal component of the tumour. The numbers of intratumoral CD8+ cells/mm2222 CONCLUSIONS: Our findings suggest that the Ki67 PI and TILs could be used as prognostic markers, as a potential alternative to the Hyams grade.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Submission date :

2024-01-30T10:27:59Z
2024-04-03T12:44:03Z