Title :

Racial differences in systemic sclerosis disease presentation: a european scleroderma trials and research group study

Author(s) :

Jaeger, Veronika K. [Auteur]
Tikly, Mohammed [Auteur]
Xu, Dong [Auteur]
Siegert, Elise [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Lille Inflammation Research International Center - U 995 [LIRIC]
Airo, Paolo [Auteur]
Valentini, Gabriele [Auteur]
Matucci-Cerinic, Marco [Auteur]
Distler, Oliver [Auteur]
Cozzi, Franco [Auteur]
Carreira, Patricia E. [Auteur]
Allanore, Yannick [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Muller-Ladner, Ulf [Auteur]
Ananieva, Lidia P. [Auteur]
Balbir-Gurman, Alexandra [Auteur]
Distler, Jorg H. W. [Auteur]
Czirjak, Laszlo [Auteur]
Li, Mengtao [Auteur]
Henes, Jorg [Auteur]
Jimenez, Sergio A. [Auteur]
Smith, Vanessa [Auteur]
Damjanov, Nemanja [Auteur]
Denton, Christopher P. [Auteur]
Del Galdo, Francesco [Auteur]
Saketkoo, Lesley Ann [Auteur]
Walker, Ulrich A. [Auteur]

Journal title :

Rheumatology

Abbreviated title :

Rheumatology (Oxford)

Volume number :

59

Publication date :

2020-07

ISSN :

1462-0332

English keyword(s) :

races
organ manifestations
systemic sclerosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical ...
Show more >OBJECTIVE: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. METHODS: SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. RESULTS: The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. CONCLUSIONS: Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:28:31Z
2024-04-25T13:47:31Z