Title :

Performance of DETECT PAH algorithm according to the hemodynamic definition of pulmonary arterial hypertension (PAH) in the 2022 ESC/ERS guidelines: Early detection of pulmonary arterial hypertension in systemic sclerosis patients.

Author(s) :

Distler, Oliver [Auteur]
University hospital of Zurich [Zurich]
Bonderman, Diana [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Coghlan, J. Gerry [Auteur]
Royal Free Hospital [London, UK]
Denton, Christopher P. [Auteur]
Royal Free Hospital [London, UK]
Grünig, Ekkehard [Auteur]
Heidelberg University Hospital [Heidelberg]
Khanna, Dinesh [Auteur]
University of Michigan [Ann Arbor]
Mclaughlin, Vallerie V. [Auteur]
University of Michigan [Ann Arbor]
Müller-Ladner, Ulf [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Pope, Janet E. [Auteur]
University of Western Ontario [UWO]
Vonk, Madelon C. [Auteur]
Radboud University Medical Center [Nijmegen]
Di Scala, Lilla [Auteur]
Lemarie, Jean-Christophe [Auteur]
Perchenet, Loïc [Auteur]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

Arthritis & rheumatology

Abbreviated title :

Arthritis Rheumatol

Publication date :

2023-12-27

ISSN :

2326-5205

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The evidence-based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in systemic sclerosis (SSc) patients to help clinicians screen for PAH by using non-invasive data to recommend patient referral ...
Show more >The evidence-based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in systemic sclerosis (SSc) patients to help clinicians screen for PAH by using non-invasive data to recommend patient referral to echocardiography, and if applicable, for a diagnostic right heart catheterization (RHC). However, the hemodynamic definition of PAH was recently updated in the 2022 ESC/ERS guidelines. The performance of DETECT PAH in identifying patients with a high risk of PAH according to this new definition was assessed. Methods In this post-hoc analysis of DETECT, which comprised 466 SSc patients the performance of the DETECT PAH algorithm in identifying patients with a high risk of PAH as defined in the 2022 ESC/ERS guidelines (mean pulmonary arterial pressure [mPAP] >20 mmHg, pulmonary capillary wedge pressure [PCWP] ≤15 mmHg, pulmonary vascular resistance [PVR] >2 Wood Units was assessed using summary statistics and was descriptively compared to the known performance of DETECT PAH as defined in 2014 when it was developed (mPAP ≥25 mmHg and PCWP ≤15 mmHg). Results The sensitivity of DETECT PAH in identifying patients with a high risk of PAH according to the 2022 ESC/ERS definition was lower (88.2%) compared to the 2014 definition (95.8%). Specificity improved from 47.8% to 50.8%. Conclusion The performance of the DETECT algorithm to screen for PAH in SSc patients is maintained when PAH is defined according to the 2022 ESC/ERS hemodynamic definition, indicating that DETECT remains applicable to screen for PAH in SSc patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-06T22:13:50Z
2024-03-20T14:21:25Z