Titre :

Mouth opening in systemic sclerosis: A longitudinal analysis from the French National Cohort Study.

Auteur(s) :

Chaigne, Benjamin [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Hôpital Cochin [AP-HP]
Bense, Alexandre [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Hôpital Cochin [AP-HP]
Agard, Christian [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Allanore, Yannick [Auteur]
Hôpital Cochin [AP-HP]
Pugnet, Grégory [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Avouac, Jérôme [Auteur]
Hôpital Cochin [AP-HP]
Bienvenu, Boris [Auteur]
Palat, Sylvain [Auteur]
CHU Limoges
Grange, Claire [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Berthier, Sabine [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Chatelus, Emmanuel [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Rivière, Sébastien [Auteur]
CHU Saint-Antoine [AP-HP]
Truchetet, Marie-Elise [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Kahn, Jean-Emmanuel [Auteur]
Hôpital Ambroise Paré [AP-HP]
Maurier, François [Auteur]
Centre hospitalier régional Metz-Thionville [CHR Metz-Thionville]
Diot, Elisabeth [Auteur]
CHU Trousseau [Tours]
Berezne, Alice [Auteur]
Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]
Mouthon, Luc [Auteur]
Hôpital Cochin [AP-HP]
Amoura, Z. [Auteur]
Aouba, A. [Auteur]
Smets, P. [Auteur]
Balquet, M. H. [Auteur]
Baudet, A. [Auteur]
Bonnotte, B. [Auteur]
De Boysson, H. [Auteur]
Cazalets, C. [Auteur]
Cottin, V. [Auteur]
Couderc, L. J. [Auteur]
Dhote, R. [Auteur]
Fauchais, A. L. [Auteur]
Goulenok, T. [Auteur]
Harle, J. R. [Auteur]
Hot, A. [Auteur]
Imbert, B. [Auteur]
Lega, J. C. [Auteur]
Lequellec, A. [Auteur]
Lidove, O. [Auteur]
Liozon, E. [Auteur]
Bertrand, N. M. [Auteur]
Mékinian, A. [Auteur]
Pennaforte, J. L. [Auteur]
Queyrel, V. [Auteur]
Wahl, D. [Auteur]

Titre de la revue :

Journal of Internal Medicine

Nom court de la revue :

J Intern Med

Date de publication :

2023-06-29

ISSN :

1365-2796

Mot(s)-clé(s) en anglais :

disease severity
mouth opening
prognosis
survival
systemic sclerosis

Résumé en anglais : [en]

Background Few studies have evaluated mouth opening (MO) in systemic sclerosis (SSc). None have studied MO trajectories. Objective To study MO trajectories in SSc. Methods This multicentre study included patients ...
Lire la suite >Background Few studies have evaluated mouth opening (MO) in systemic sclerosis (SSc). None have studied MO trajectories. Objective To study MO trajectories in SSc. Methods This multicentre study included patients enrolled in the French national SSc cohort with at least one MO assessment, described patients based on MO baseline measure, modelled MO trajectories and associated MO measures with SSc prognosis. Results We included 1101 patients. Baseline MO was associated with disease severity. On Kaplan–Meier analysis, MO <30 mm was associated with worse 30-year-survival (p < 0.01) and risk of pulmonary arterial hypertension (p < 0.05). Individual MO trajectories were heterogenous among patients. The best model of MO trajectories according to latent-process mixed modelling showed that 88.8% patients had a stable MO trajectory and clustered patients into three groups that predicted SSc survival (p < 0.05) and interstitial lung disease (ILD) occurrence (p < 0.05). The model highlighted a cluster of 9.5% patients with diffuse cutaneous SSc (dcSSc) (p < 0.05) and high but decreasing MO over 1 year (p < 0.0001) who were at increased risk of poor survival and ILD. Conclusion MO, which is a simple and reliable measure, could be used to predict disease severity and survival in SSc. Although MO remained stable in most SSc patients, dcSSc patients with high but decreasing MO were at risk of poor survival and ILD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-02-06T22:34:54Z
2024-03-15T12:52:37Z