Title :

Coronary and Abdominal Aorta Calcification in Rheumatoid Arthritis: Relationships with Traditional Cardiovascular Risk Factors, Disease Characteristics, and Concomitant Treatments

Author(s) :

Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Université de Lille
Renard, Cédric [Auteur]
CHU Amiens-Picardie
Liabeuf, Sophie [Auteur]
Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 [MP3CV]
Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie]
Kamel, Said [Auteur]
Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 [MP3CV]
Fardellone, Patrice [Auteur]
Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux
Massy, Ziad [Auteur]
Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]
Brazier, Michel [Auteur]
Mentaverri, Romuald [Auteur]
Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie]
Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 [MP3CV]

Journal title :

Journal of Rheumatology

Pages :

2137-2144

Publisher :

Journal of Rheumatology Publishing Company Limited

Publication date :

2014-11-01

ISSN :

0315-162X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective. To assess the influence of traditional cardiovascular (CV) risk factors, disease characteristics, and concomitant treatments in patients with rheumatoid arthritis (RA) on coronary artery calcification (CAC) and ...
Show more >Objective. To assess the influence of traditional cardiovascular (CV) risk factors, disease characteristics, and concomitant treatments in patients with rheumatoid arthritis (RA) on coronary artery calcification (CAC) and abdominal aorta calcification (AAC). Methods. In our cross-sectional study, 75 patients with RA were compared with 75 age-matched and sex-matched control participants. The CAC and AAC scores were measured by computed tomography in patients with no clinical evidence of coronary artery disease. The relationships between the presence or absence of CAC and AAC and traditional CV risk factors, disease characteristics, and concomitant treatments in patients with RA were assessed in a multiple logistic regression analysis. Results. The RA and control groups did not differ significantly in terms of age, sex composition, or the prevalence of traditional CV risk factors. AAC and CAC were more prevalent and severe in patients with RA than in controls. Older age (OR = 1.15, p < 0.01) and hypertension (OR = 3.77, p = 0.04) were found to be independently associated with CAC, whereas current use of methotrexate (MTX; OR = 0.12, p = 0.01) was found to be associated with the absence of CAC. Older age (OR per yr = 1.17, p < 0.001) and erosive arthritis (OR = 3.78, p = 0.03) were found to be independently associated with AAC. Conclusion. Our study demonstrates that in patients with RA, (1) CAC and AAC are more prevalent and more severe compared with age-matched and sex-matched control participants, (2) current use of MTX is a major determinant of the absence of CAC, and (3) erosive arthritis is a major determinant of AAC.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL