Titre :

Impact of mismatch repair deficiency on tumour regression grade after neoadjuvant chemotherapy in localized gastroesophageal adenocarcinoma

Auteur(s) :

Heran, Maximilien [Auteur]
CHU Saint-Antoine [AP-HP]
Renaud, Florence [Auteur]
Hôpital Claude Huriez [Lille]
Louvet, Christophe [Auteur]
Institut Mutualiste de Montsouris [IMM]
Piessen, Guillaume [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Voron, Thibault [Auteur]
CHU Saint-Antoine [AP-HP]
Lefèvre, Marine [Auteur]
Institut Mutualiste de Montsouris [IMM]
Dubreuil, Olivier [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
André, Thierry [Auteur]
CHU Saint-Antoine [AP-HP]
Instabilité des microsatellites et cancers [CRSA]
Svrcek, Magali [Auteur]
CHU Saint-Antoine [AP-HP]
Cohen, Romain [Auteur]
CHU Saint-Antoine [AP-HP]
Instabilité des microsatellites et cancers [CRSA]

Titre de la revue :

Digestive and Liver Disease

Éditeur :

Elsevier

Date de publication :

2022-06-29

ISSN :

1590-8658

Mot(s)-clé(s) en anglais :

Biomarker
Gastric cancer
Localized cancer
Microsatellite instability
Mismatch repair

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: The use of neoadjuvant chemotherapy (NAC) in patients with mismatch repair (MMR) deficient (dMMR) localized gastric and oeso-gastric junction (OGJ) adenocarcinoma is subject of debate. Histological response ...
Lire la suite >Background: The use of neoadjuvant chemotherapy (NAC) in patients with mismatch repair (MMR) deficient (dMMR) localized gastric and oeso-gastric junction (OGJ) adenocarcinoma is subject of debate. Histological response assessment might help to better evaluate the impact of dMMR on response to NAC.Methods: Patients with localized gastric/OGJ adenocarcinoma resected after NAC were retrospectively identified. MMR protein expression status was assessed by immunohistochemistry. The primary objective was the frequency of histological responders to NAC defined by tumour regression grade (TRG) using Mandard's (TRG1-2) and Becker's (TRG1) classifications, according to the MMR status.Results: In total, 247 patients with 43 dMMR and 204 pMMR gastric/OGJ adenocarcinoma were identified. Among dMMR tumours, 18 (42%) arose from the OGJ. Histological response (Becker TRG1-2) was observed for 28% and 35% of dMMR and pMMR tumours, respectively (p = 0.35). Similar results were observed with Mandard classification. With a median follow-up of 37.5 months, median disease-free and overall survival were not reached for the dMMR group.Conclusion: Histological response after NAC in patients with localized dMMR gastric/OGJ adenocarcinoma is not statistically different to those with pMMR tumours. This study provides additional data for the discussion about avoiding NAC in patients with dMMR gastric/OGJ adenocarcinomas.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Date de dépôt :

2024-02-17T03:50:44Z