Titre :

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians

Auteur(s) :

Póvoa, Pedro [Auteur]
Odense University Hospital [OUH]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Coelho, Luís [Auteur]
NOVA Medical School - Faculdade de Ciências Médicas [NMS]
Dal-Pizzol, Felipe [Auteur]
University of Southern Santa Catarina [Florianopolis] [UNISUL]
Ferrer, Ricard [Auteur]
Vall d'Hebron University Hospital [Barcelona]
Centro de Investigación Biomédica en Red Enfermedades Respiratorias [CIBERES]
Huttner, Angela [Auteur]
Geneva University Hospitals and Geneva University
Conway Morris, Andrew [Auteur]
University of Cambridge [UK] [CAM]
Nobre, Vandack [Auteur]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] [UFMG]
Ramirez, Paula [Auteur]
Centro de Investigación Biomédica en Red Enfermedades Respiratorias [CIBERES]
Rouze, Anahita [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Salluh, Jorge [Auteur]
D'Or Institute for Research and Education [Rio de Janeiro]
Universidade Federal do Estado do Rio de Janeiro [UNIRIO]
Singer, Mervyn [Auteur]
University College of London [London] [UCL]
Sweeney, Daniel A. [Auteur]
University of California [San Diego] [UC San Diego]
Torres, Antoni [Auteur]
Universitat de Barcelona [UB]
Centro de Investigación Biomédica en Red Enfermedades Respiratorias [CIBERES]
Waterer, Grant [Auteur]
Royal Perth Hospital
Kalil, Andre C. [Auteur]
University of Nebraska Medical Center

Titre de la revue :

Intensive Care Medicine

Nom court de la revue :

Intensive Care Med

Numéro :

49

Pagination :

142-153

Éditeur :

Springer Science and Business Media LLC

Date de publication :

2023-01-02

ISSN :

0342-4642

Mot(s)-clé(s) en anglais :

Sepsis
Intensive care unit
Biomarkers
Diagnosis
Antibiotic stewardship

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response ...
Lire la suite >Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response or response to treatment and/or aid clinicians to prognosticate patient risk. More than 250 biomarkers have been identified and evaluated over the last few decades, but no biomarker accurately differentiates between sepsis and sepsis-like syndrome. Published data support the use of biomarkers for pathogen identification, clinical diagnosis, and optimization of antibiotic treatment. In this narrative review, we highlight how clinicians could improve the use of pathogen-specific and of the most used host-response biomarkers, procalcitonin and C-reactive protein, to improve the clinical care of patients with sepsis. Biomarker kinetics are more useful than single values in predicting sepsis, when making the diagnosis and assessing the response to antibiotic therapy. Finally, integrated biomarker-guided algorithms may hold promise to improve both the diagnosis and prognosis of sepsis. Herein, we provide current data on the clinical utility of pathogen-specific and host-response biomarkers, offer guidance on how to optimize their use, and propose the needs for future research.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Glycobiology in fungal Pathogenesis and Clinical Applications

Date de dépôt :

2024-03-01T13:42:45Z
2024-03-05T10:35:26Z