Title :

Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients

Author(s) :

de Boysson, Hubert [Auteur]
Service de médecine interne [CHU Caen]
Daumas, Aurélie [Auteur]
Aix Marseille Université [AMU]
Vautier, Mathieu [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Parienti, Jean-Jacques [Auteur]
Unité de Biostatistique et de Recherche Clinique [UBRC]
Liozon, Eric [Auteur]
Service de Médecine interne A et polyclinique médicale [CHU Limoges]
Lambert, Marc [Auteur]
Service de médecine interne [Lille]
Lille Inflammation Research International Center - U 995 [LIRIC]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Samson, Maxime [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Ebbo, Mikael [Auteur]
Médecine Interne [Hôpital Saint-Joseph - Marseille]
Dumont, Anael [Auteur]
Service de médecine interne [CHU Caen]
Sultan, Audrey [Auteur]
Service de médecine interne [CHU Caen]
Bonnotte, Bernard [Auteur]
Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon]
Manrique, Alain [Auteur]
Service de médecine nucléaire [CHU Caen]
Bienvenu, Boris [Auteur]
Service de médecine interne [CHU Caen]
Saadoun, David [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Centre National de la Recherche Scientifique [CNRS]
Aouba, Achille [Auteur]
Service de médecine interne [CHU Caen]

Journal title :

AUTOIMMUNITY REVIEWS

Pages :

p.391-398

Publisher :

Elsevier

Publication date :

2018-04

ISSN :

1568-9972

English keyword(s) :

Aortic dilation
Giant-cell arteritis
Aortitis Large-vessel involvement

HAL domain(s) :

Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie

English abstract : [en]

ObjectivesLarge-vessel involvement (LVI) can occur in giant-cell arteritis (GCA) and may represent a distinct disease subgroup with a higher risk for aortic dilation. This study aimed to better characterize the presentation ...
Show more >ObjectivesLarge-vessel involvement (LVI) can occur in giant-cell arteritis (GCA) and may represent a distinct disease subgroup with a higher risk for aortic dilation. This study aimed to better characterize the presentation and evolution of LVI in patients with GCA.Patients and methodsA retrospective multicenter study enrolled 248 GCA patients with LVI and 301 GCA patients without LVI on imaging. Factors associated with aortic dilation were identified in a multivariable model.ResultsThe patients with LVI were younger (p < 0.0001), more likely to be women (p = 0.01), and showed fewer cephalic symptoms (p < 0.0001) and polymyalgia rheumatica (p = 0.001) but more extracranial vascular symptoms (p = 0.05) than the patients without LVI. Glucocorticoids (GC) management did not differ between the two groups, but the GC discontinuation rate was lower in the patients with LVI (p = 0.0003). Repeated aortic imaging procedures were performed at 19 months [range: 5–162 months] and 17 months [range: 6–168 months] after diagnosis in 154 patients with LVI and 123 patients without LVI, respectively, of whom 21% and 7%, respectively, presented new aortic dilations (p = 0.0008). In the patients with LVI, aortic dilation occurred on an aorta segment shown to be inflammatory on previous imaging in 94% of patients. In the multivariate analysis, LVI was the strongest predictor of aortic dilation (hazard ratio: 3.16 [range: 1.34–7.48], p = 0.009).ConclusionsLVI represents a distinct disease pattern of GCA with an increased risk of aortic dilation. Control of the aortic morphology during follow-up is required.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL