Title :

Structural and functional papez circuit integrity in amyotrophic lateral sclerosis.

Author(s) :

Bueno, A. P. A. [Auteur]
Universidade Federal do ABC = Federal University of ABC = Université Fédérale de l'ABC [Brazil] [UFABC]
Pinaya, W. H. L. [Auteur]
Universidade Federal do ABC = Federal University of ABC = Université Fédérale de l'ABC [Brazil] [UFABC]
Moura, L. M. [Auteur]
Universidade Federal do ABC = Federal University of ABC = Université Fédérale de l'ABC [Brazil] [UFABC]
Bertoux, Maxime [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Radakovic, R. [Auteur]
University of East Anglia [Norwich] [UEA]
University of Edinburgh [Edin.]
Kiernan, M. C. [Auteur]
The University of Sydney
Teixeira, A. L. [Auteur]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] [UFMG]
De Souza, L. C. [Auteur]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] [UFMG]
Hornberger, M. [Auteur]
University of East Anglia [Norwich] [UEA]
Sato, J. R. [Auteur]
Universidade Federal do ABC = Federal University of ABC = Université Fédérale de l'ABC [Brazil] [UFABC]

Journal title :

Brain Imaging Behav

Abbreviated title :

Brain Imaging Behav

Volume number :

12

Pages :

1622-1630

Publication date :

2024-03-11

ISSN :

1931-7565

English keyword(s) :

Multimodal MRI
Papez circuit
Episodic memory
Cognitive deficits
Amyotrophic lateral sclerosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cognitive impairment in amyotrophic lateral sclerosis (ALS) is heterogeneous but now recognized as a feature in non-demented patients and no longer exclusively attributed to executive dysfunction. However, despite common ...
Show more >Cognitive impairment in amyotrophic lateral sclerosis (ALS) is heterogeneous but now recognized as a feature in non-demented patients and no longer exclusively attributed to executive dysfunction. However, despite common reports of temporal lobe changes and memory deficits in ALS, episodic memory has been less explored. In the current study, we examined how the Papez circuit-a circuit known to participate in memory processes-is structurally and functionally affected in ALS patients (n = 20) compared with healthy controls (n = 15), and whether these changes correlated with a commonly used clinical measure of episodic memory. Our multimodal MRI approach (cortical volume, voxel-based morphometry, diffusion tensor imaging and resting state functional magnetic resonance) showed reduced gray matter in left hippocampus, left entorhinal cortex and right posterior cingulate as well as increased white matter fractional anisotropy and decreased mean diffusivity in the left cingulum bundle (hippocampal part) of ALS patients compared with controls. Interestingly, thalamus, mammillary bodies and fornix were preserved. Finally, we report a decreased functional connectivity in ALS patients in bilateral hippocampus, bilateral anterior and posterior parahippocampal gyrus and posterior cingulate. The results revealed that ALS patients showed statistically significant structural changes, but more important, widespread prominent functional connectivity abnormalities across the regions comprising the Papez circuit. The decreased functional connectivity found in the Papez network may suggest these changes could be used to assess risk or assist early detection or development of memory symptoms in ALS patients even before structural changes are established.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2024-03-12T22:14:53Z
2024-12-11T09:19:01Z