Title :

The histone lysine methyltransferase Ezh2 is required for maintenance of the intestine integrity and for caudal fin regeneration in zebrafish

Author(s) :

Dupret, Barbara [Auteur]
Völkel, Pamela [Auteur]
Vennin, Constance [Auteur]
Toillon, Robert-Alain [Auteur]
Le Bourhis, Xuefen [Auteur]
Angrand, Pierre-Olivier [Auteur correspondant]
Université de Lille
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Journal title :

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Pages :

1079-1093

Publisher :

Elsevier

Publication date :

2017-10

ISSN :

1874-9399

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

HIGHLIGHTS  Zebrafish ezh2-/-mutants gastrulate properly and present a normal body plan.  Zebrafish ezh2-/-mutants die at 12 dpf with defects of the intestine wall.  Ezh2 function is required for intestine and exocrine ...
Show more >HIGHLIGHTS  Zebrafish ezh2-/-mutants gastrulate properly and present a normal body plan.  Zebrafish ezh2-/-mutants die at 12 dpf with defects of the intestine wall.  Ezh2 function is required for intestine and exocrine pancreas maintenance.  Loss of Ezh2 function is responsible for a strong increase in apoptosis.  Ezh2 is required for regeneration of the larval caudal spinal cord after transection.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL