Titre :

The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates

Auteur(s) :

Hanot, Mariette [Auteur]
Raby, Ludivine [Auteur]
Völkel, Pamela [Auteur]
Le Bourhis, Xuefen [Auteur]
Angrand, Pierre-Olivier [Auteur correspondant]
Université de Lille
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Titre de la revue :

International Journal of Molecular Sciences

Pagination :

2322

Éditeur :

MDPI

Date de publication :

2023-01-24

ISSN :

1661-6596

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Polycomb group (PcG) proteins are highly conserved proteins assembled into two major types of complexes, PRC1 and PRC2, involved in the epigenetic silencing of a wide range of gene expression programs regulating cell fate ...
Lire la suite >Polycomb group (PcG) proteins are highly conserved proteins assembled into two major types of complexes, PRC1 and PRC2, involved in the epigenetic silencing of a wide range of gene expression programs regulating cell fate and tissue development. The crucial role of PRC1 and PRC2 in the fundamental cellular processes and their involvement in human pathologies such as cancer attracted intense attention over the last few decades. Here, we review recent advancements regarding PRC1 and PRC2 function using the zebrafish model. We point out that the unique characteristics of the zebrafish model provide an exceptional opportunity to increase our knowledge of the role of the PRC1 and PRC2 complexes in tissue development, in the maintenance of organ integrity and in pathology.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL