Title :

Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study

Author(s) :

Chetboun, Mikael [Auteur]
Masset, Christophe [Auteur]
Maanaoui, Mehdi [Auteur]
Defrance, Frédérique [Auteur]
Gmyr, Valéry [Auteur]
Raverdy, Violeta [Auteur]
Hubert, Thomas [Auteur]
Bonner, Caroline [Auteur]
Supiot, Lisa [Auteur]
Kerleau, Clarisse [Auteur]
Blancho, Gilles [Auteur]
Branchereau, Julien [Auteur]
Karam, Georges [Auteur]
Chelghaf, Ismaël [Auteur]
Houzet, Aurélie [Auteur]
Giral, Magali [Auteur]
Garandeau, Claire [Auteur]
Dantal, Jacques [Auteur]
Le Mapihan, Kristell [Auteur]
Jannin, Arnaud [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Hazzan, Marc [Auteur]
Caiazzo, Robert [Auteur]
Kerr-Conte, Julie [Auteur]
Vantyghem, Marie-Christine [Auteur]
Cantarovich, Diego [Auteur]
Pattou, François [Auteur]

Journal title :

Transplant International

Publisher :

Frontiers Media

Publication date :

2023-12-28

ISSN :

0934-0874

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and ...
Show more >In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

EGID Diabetes Pole

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL