Titre :

The amount of signet ring cells is significantly associated with tumour stage and survival in gastric poorly cohesive tumours

Auteur(s) :

Bencivenga, Maria [Auteur]
Treppiedi, Elio [Auteur]
Dal Cero, Mariagiulia [Auteur]
Torroni, Lorena [Auteur]
Verlato, Giuseppe [Auteur]
Iglesias, Mar [Auteur]
Renaud, Florence [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Tomezzoli, Anna [Auteur]
Castelli, Claudia [Auteur]
Piessen, Guillaume [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Pera, Manuel [Auteur]
de Manzoni, Giovanni [Auteur]

Titre de la revue :

JOURNAL OF SURGICAL ONCOLOGY

Pagination :

1084-1089

Éditeur :

Wiley-Blackwell

Date de publication :

2020-03-09

ISSN :

0022-4790

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

Abstract Background and Objectives The aim of this study was to evaluate whether the amount of signet ring cells (SRCs) affects clinicopathological characteristics and prognosis of poorly cohesive (PC) gastric tumours. ...
Lire la suite >Abstract Background and Objectives The aim of this study was to evaluate whether the amount of signet ring cells (SRCs) affects clinicopathological characteristics and prognosis of poorly cohesive (PC) gastric tumours. Study design One hundred seventy‐three patients with PC tumours treated at three European centres from 2004 to 2014 were reclassified in three categories: (a) pure SRC cancers (SRC1) (≥90% SRCs); (b) PC carcinoma with SRC component (SRC2) (>10%, <90% SRCs); (c) PC carcinoma not otherwise specified (SRC3) (≤10% SRCs). Results The percentage of SRCs was inversely related to the pT stage (Spearman's ρ = −0.174, P < .001) and the number of positive nodes coded as a continuous variable ( P = .009). Five year cancer‐related survival was significantly higher (58%, 95% confidence interval [CI]: 36%‐75%) in SRC1 compared with SRC2 (39%, 95% CI: 28%‐50%) and SRC3 (38%, 95% CI: 22%‐53%), ( P = .048). In multivariable analysis, the impact of PC categories on cancer‐related survival was significant when controlling for sex, age, pT, pN, and curativity (hazard ratio [HR] of sSRC2 vs SRC1 = 2.08, 95% CI: 1.01‐4.29, P = .046; HR of SRC3 vs SRC1 = 2.38, 95% CI: 1.05‐5.41, P = .039). Conclusion The percentage of SRCs was inversely related to tumour aggressiveness, with long‐term survival significantly higher in SRC1 compared with SRC2 and SRC3 tumours.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL