Title :

Angioedema associated with thrombolysis for ischemic stroke: analysis of a case-control study

Author(s) :

Vigneron, Clara [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Lecluse, Alderic [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Ronziere, Thomas [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Bouillet, Laurence [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Boccon-Gibod, Isabelle [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Gayet, Stephane [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Doche, Emilie [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Smadja, Didier [Auteur]
Centre Hospitalier Sud Francilien
Di Legge, Silvia [Auteur]
Centre Hospitalier du Pays d'Aix
Dumont, Frederic [Auteur]
Territoires, Villes, Environnement & Société - ULR 4477 [TVES]
Gaudron, Marie [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Ion, Ioana [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Marcel, Sebastien [Auteur]
Centre Hospitalier Métropole Savoie [Chambéry]
Sevin, Mathieu [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Vlaicu, Mihaela Bustuchina [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Arnaud, Isaure [Auteur]
Girard-Madoux, Philippe [Auteur]
Heroum, Cherif [Auteur]
Lefevre, Sebastien [Auteur]
Centre hospitalier régional Metz-Thionville [CHR Metz-Thionville]
Marc, Guillaume [Auteur]
Centre hospitalier de Saint-Nazaire
Obadia, Michael [Auteur]
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
Sablot, Denis [Auteur]
Centre Hospitalier Saint Jean de Perpignan
Sibon, Igor [Auteur]
Université de Bordeaux [UB]
Suissa, Laurent [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Gobert, Delphine [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Detante, Olivier [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Alamowitch, Sonia [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Fain, Olivier [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Javaud, Nicolas [Auteur]
Université Paris Diderot - Paris 7 [UPD7]

Journal title :

Journal of Internal Medicine

Pages :

702-710

Publisher :

Wiley

Publication date :

2019-12-01

ISSN :

0954-6820

English keyword(s) :

bradykinin
angioedema
alteplase
ischemic stroke

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed.To clarify risk factors associated with bradykinin-mediated ...
Show more >Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed.To clarify risk factors associated with bradykinin-mediated AE after thrombolysis for acute ischemic stroke.In a case-control study conducted at a French reference centre for bradykinin angiœdema, patients with thrombolysis for acute ischemic stroke and a diagnosis of bradykinin-mediated angiœdema, were compared to controls treated with thrombolysis treatment without angiœdema.Fifty-three thrombolysis-related AE were matched to 106 control subjects. The sites of attacks following thrombolysis for ischemic stroke mainly included tongue (34/53, 64%) and lips (26/53, 49%). The upper airways were involved in 37 (70%) cases. Three patients required mechanical ventilation. Patients with bradykinin-mediated angiœdema were more frequently women [33 (62%) vs. 44 (42%); P = 0.01], had higher frequency of prior ischemic stroke [12 (23%) vs. 9 (8%); P = 0.01], hypertension [46 (87%) vs. 70 (66%); P = 0.005], were more frequently treated with angiotensin-converting enzyme inhibitor [37 (70%) vs. 28 (26%); P < 0.001] and were more frequently hospitalized in intensive care medicine [ICU; 11 (21%) vs. 5 (5%); P = 0.004]. In multivariate analysis, factors associated with thrombolysis-related AE were female sex [odds ratio (OR), 3.04; 95% confident interval (CI), 1.32-7.01; P = 0.009] and treatment with angiotensin-converting enzyme inhibitors [(OR), 6.08; 95% (CI), 2.17-17.07; P < 0.001].This case-control study points out angiotensin-converting enzyme inhibitors and female sex as risk factors of bradykinin AE associated with thrombolysis for ischemic stroke.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Territoires, Villes, Environnement & Société (TVES) - ULR 4477

Source :

Harvested from HAL