Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines

Carpentier, Rodolphe; Platel, Anne; Salah, Norhane; Nesslany, Fabrice; Betbeder, Didier

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1155/2018/9067195

URL permanente :

http://hdl.handle.net/20.500.12210/11208

Titre :

Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines

Auteur(s) :

Carpentier, Rodolphe [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Platel, Anne [Auteur]

Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Salah, Norhane [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Nesslany, Fabrice [Auteur]

Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Betbeder, Didier [Auteur]

498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Université d'Artois [UA]

Titre de la revue :

Journal of Nanomaterials

Nom court de la revue :

J. Nanomater.

Numéro :

2018

Pagination :

ID 9067195

Éditeur :

Hindawi Publishing Corporation

Date de publication :

2018-12-16

ISSN :

1687-4110

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases. The nanoparticles studied are cationic maltodextrin-based nanoparticles ...
Lire la suite >Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases. The nanoparticles studied are cationic maltodextrin-based nanoparticles with an anionic phospholipid core (NPL); they are a promising antigen delivery system, and their efficacy as drug vectors against complex diseases such as toxoplasmosis has already been demonstrated. Cationic compounds are generally described as toxic; therefore, it is of interest to evaluate the behavior of these NPL in vitro and in vivo. Here, we studied the in vitro toxicity (cytotoxicity and ROS induction in intestinal and airway epithelial cell lines) and the in vivo tolerability and genotoxicity of these nanoparticles administered by the nasal route to a rodent model. In vitro, these NPL were not cytotoxic and did not induce any ROS production. In vivo, even at very large doses (1000 times the expected human dose), no adverse effect and no genotoxicity were observed in lungs, stomach, colon, or liver. This study shows that these NPL can be safely used.Lire moins >

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille
Institut Pasteur de Lille

Collections :

Équipe(s) de recherche :

Therapeutic innovation targetting inflammation

Date de dépôt :

2019-05-17T13:08:37Z
2021-06-23T07:08:33Z
2022-11-21T15:37:56Z

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Ce document est diffusé sous licence Attribution 3.0 United States

Historique des modifications

Numéro de version	Lien	Date de modification
3	20.500.12210/11208*	2022-11-21T15:29:16Z
2	20.500.12210/11208.2	2021-06-23T07:07:48Z
1	20.500.12210/11208.1	2019-05-17T13:08:37Z

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