Development of prilling process for ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Development of prilling process for biodegradable microspheres through experimental designs
Auteur(s) :
Violet, Fabien [Auteur]
Le, Minh-Quan [Auteur]
Michelle, Sergent [Auteur]
Guillaume, Bastiat [Auteur]
Tran, Van-Thanh [Auteur]
Venier-Julienne, Marie-Claire [Auteur]
Le, Minh-Quan [Auteur]
Michelle, Sergent [Auteur]
Guillaume, Bastiat [Auteur]
Tran, Van-Thanh [Auteur]
Venier-Julienne, Marie-Claire [Auteur]
Titre de la revue :
International journal of pharmaceutics
Nom court de la revue :
Int. J. Pharm.
Numéro :
498
Pagination :
96-109
Date de publication :
2016-02-10
ISSN :
0378-5173
Mot(s)-clé(s) en anglais :
Glycofurol
Prilling
PLGA
Microsphere
Experimental design
Prilling
PLGA
Microsphere
Experimental design
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an ...
Lire la suite >The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an encapsulated protein and adhered stem cells on its surface, proposing a tool for regeneration therapy against injured tissue. This work focused on the development of the production of PLGA microspheres by the prilling process without toxic solvent. The required production quality needed a complete optimization of the process. Seventeen parameters were studied through experimental designs and led to an acceptable production. The key parameters and mechanisms of formation were highlighted.Lire moins >
Lire la suite >The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an encapsulated protein and adhered stem cells on its surface, proposing a tool for regeneration therapy against injured tissue. This work focused on the development of the production of PLGA microspheres by the prilling process without toxic solvent. The required production quality needed a complete optimization of the process. Seventeen parameters were studied through experimental designs and led to an acceptable production. The key parameters and mechanisms of formation were highlighted.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Équipe(s) de recherche :
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-05-17T13:14:37Z