Synthetic parasites: a successful mucosal ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Auteur(s) :
Ducournau, Celine [Auteur]
Nguyen, Thi Tl [Auteur]
Carpentier, Rodolphe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lantier, Isabelle [Auteur]
Germon, Stephanie [Auteur]
Precausta, Flavien [Auteur]
Pisella, Pierre-Jean [Auteur]
Leroux, Herve [Auteur]
Langendonck, Nathalie Van [Auteur]
Betbeder, Didier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dimier-Poisson, Isabelle [Auteur]
Nguyen, Thi Tl [Auteur]
Carpentier, Rodolphe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lantier, Isabelle [Auteur]
Germon, Stephanie [Auteur]
Precausta, Flavien [Auteur]
Pisella, Pierre-Jean [Auteur]
Leroux, Herve [Auteur]
Langendonck, Nathalie Van [Auteur]
Betbeder, Didier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dimier-Poisson, Isabelle [Auteur]
Titre de la revue :
Future microbiology
Nom court de la revue :
Future Microbiol.
Numéro :
12
Pagination :
393-405
Date de publication :
2017-04-01
ISSN :
1746-0913
Mot(s)-clé(s) en anglais :
congenital toxoplasmosis
nasal vaccination
nanoparticles
nasal vaccination
nanoparticles
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis.Mice ...
Lire la suite >Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis.Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied.Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated.Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.Lire moins >
Lire la suite >Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis.Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied.Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated.Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Équipe(s) de recherche :
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-05-17T13:14:41Z