Punching Holes in Cellular Membranes: ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins
Author(s) :
de Schutter, Elke [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
University of Antwerp [UA]
Roelandt, Ria [Auteur]
Riquet, Franck B. [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
van Camp, Guy [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Wullaert, Andy [Auteur]
Ghent University Hospital
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
University of Antwerp [UA]
Vandenabeele, Peter [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
University of Antwerp [UA]
Roelandt, Ria [Auteur]
Riquet, Franck B. [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
van Camp, Guy [Auteur]
University of Antwerp [UA]
Antwerp University Hospital [Edegem] [UZA]
Wullaert, Andy [Auteur]
Ghent University Hospital
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
University of Antwerp [UA]
Vandenabeele, Peter [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
VIB-UGent Center for Inflammation Research [Gand, Belgique] [IRC]
Journal title :
TRENDS IN CELL BIOLOGY
Pages :
500-513
Publication date :
2021
HAL domain(s) :
Physique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
English abstract : [en]
The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable ...
Show more >The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease-and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates.Show less >
Show more >The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease-and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates.Show less >
Language :
Anglais
Source :
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