Title :

High Torque teno virus load and outcome of patients undergoing allogeneic hematopoietic cell transplantation.

Author(s) :

Srour, Micha [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Grenier, Corentin [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Magro, Leonardo [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hober, Didier [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Engelmann, Ilka [Auteur]
Université de Montpellier [UM]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]

Journal title :

Journal of Medical Virology

Abbreviated title :

J Med Virol

Volume number :

96

Pages :

e29458

Publication date :

2024-03

ISSN :

1096-9071

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Quantification of Torque teno virus (TTV) load emerged as a marker of immunosuppression. Associations of TTV load with complications and survival after allogeneic hematopoietic cell transplantation (allo-HCT) were controversial ...
Show more >Quantification of Torque teno virus (TTV) load emerged as a marker of immunosuppression. Associations of TTV load with complications and survival after allogeneic hematopoietic cell transplantation (allo-HCT) were controversial in published studies. In this prospective study, we aimed to identify factors influencing TTV load after allo-HCT and to determine whether the TTV load is associated with complications or outcomes. Seventy allo-HCT recipients were included. TTV DNA load was quantified in 469 plasma samples of 70 patients from Day (D) 15 before D120 after transplantation. The influence of transplant characteristics on TTV load and the associations of TTV load with viral infections, acute graft versus host disease, mortality, and relapse were analyzed. More than 80% of patients were TTV DNA positive from D30 after transplantation onwards. Median TTV load increased between D30 and D60 post-transplantation. Patients with lymphoid malignancies had higher TTV load than those with myeloid malignancies. Myeloablative conditioning was associated with higher TTV loads. Patients with no measurable residual disease at transplant had higher TTV loads. High TTV load at D90 post-transplantation was associated with lower overall survival and at D120 post-transplantation was associated with higher relapse rate. In conclusion, TTV load at time points later than D90 after allo-HCT may be useful to assess prognosis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-05-06T21:36:05Z
2024-08-19T12:24:37Z