Effects of High PEEP Ventilation on ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
URL permanente :
Titre :
Effects of High PEEP Ventilation on Intrapulmonary Shunt Ratio in Patients With SARS-CoV-2-Induced ARDS.
Auteur(s) :
Cousin, Nicolas [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
GOUTAY, Julien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cailliau, Emeline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Gaudet, Alexandre [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Duburcq, Thibault [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
GOUTAY, Julien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cailliau, Emeline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Gaudet, Alexandre [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Duburcq, Thibault [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Titre de la revue :
Respiratory Care
Éditeur :
Daedalus Enterprises Inc
Date de publication :
2022-07-15
ISSN :
0020-1324
Mot(s)-clé(s) en anglais :
COVID-19
SARS-CoV-2
ARDS
pulmonary artery catheter
intrapulmonary shunt ratio
recruitment-to-inflation ratio
SARS-CoV-2
ARDS
pulmonary artery catheter
intrapulmonary shunt ratio
recruitment-to-inflation ratio
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Early in the COVID-19 pandemic, the scientific community questioned whether this infection led to typical ARDS or not. Gattinoni et al1 proposed a subdivision of COVID-19 ARDS into 2 phenotypes: L for low elastance, ...
Lire la suite >Early in the COVID-19 pandemic, the scientific community questioned whether this infection led to typical ARDS or not. Gattinoni et al1 proposed a subdivision of COVID-19 ARDS into 2 phenotypes: L for low elastance, ventilation-perfusion ratio, lung weight, and recruitability; and H for high elastance, right-to-left shunt, lung weight, and recruitability. However, numerous studies failed to confirm these findings, leading authors to contest this classification.2 Nevertheless, the correct identification of the respiratory phenotype of COVID-19 ARDS seems of critical importance. Indeed, the use of high PEEP is expected to be beneficial in phenotype H, whereas a deleterious effect is expected in phenotype L. We conducted a study to describe early respiratory and hemodynamic modifications in response to high PEEP in subjects with COVID-19, using a pulmonary artery catheter for intrapulmonary shunt (Q̇S/Q̇T) determination and the recruitment-to-inflation (R/I) ratio to assess the lung recruitment potential. The primary objective of the study was to assess the effect of high PEEP on Q̇S/Q̇T in comparison with low PEEP. Secondary objectives were to evaluate whether high R/I correlated with a drop in Q̇S/Q̇T with low versus high PEEP and to describe advanced physiologic variables at each PEEP.Lire moins >
Lire la suite >Early in the COVID-19 pandemic, the scientific community questioned whether this infection led to typical ARDS or not. Gattinoni et al1 proposed a subdivision of COVID-19 ARDS into 2 phenotypes: L for low elastance, ventilation-perfusion ratio, lung weight, and recruitability; and H for high elastance, right-to-left shunt, lung weight, and recruitability. However, numerous studies failed to confirm these findings, leading authors to contest this classification.2 Nevertheless, the correct identification of the respiratory phenotype of COVID-19 ARDS seems of critical importance. Indeed, the use of high PEEP is expected to be beneficial in phenotype H, whereas a deleterious effect is expected in phenotype L. We conducted a study to describe early respiratory and hemodynamic modifications in response to high PEEP in subjects with COVID-19, using a pulmonary artery catheter for intrapulmonary shunt (Q̇S/Q̇T) determination and the recruitment-to-inflation (R/I) ratio to assess the lung recruitment potential. The primary objective of the study was to assess the effect of high PEEP on Q̇S/Q̇T in comparison with low PEEP. Secondary objectives were to evaluate whether high R/I correlated with a drop in Q̇S/Q̇T with low versus high PEEP and to describe advanced physiologic variables at each PEEP.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
Date de dépôt :
2024-06-20T02:12:18Z