Titre :

Subtle postoperative cognitive disorder in preclinical Alzheimer's disease.

Auteur(s) :

Glasman, P. [Auteur]
Houot, M. [Auteur]
Migliaccio, R. [Auteur]
Bombois, Stephanie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Gagliardi, G. [Auteur]
Cacciamani, F. [Auteur]
Habert, M. O. [Auteur]
Dubois, B. [Auteur]
Epelbaum, Stéphane [Auteur]
Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] [IM2A]

Titre de la revue :

Experimental Gerontology

Nom court de la revue :

Exp Gerontol

Numéro :

161

Pagination :

111715

Éditeur :

Elsevier

Date de publication :

2022-02-03

ISSN :

1873-6815

Mot(s)-clé(s) en anglais :

Post-operative cognitive disorder
Preclinical Alzheimer's disease
Longitudinal cohort study
Amyloid imaging
Generalized linear mixed models
Linear models

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background We examined the association between preclinical Alzheimer's disease (AD) and undergoing anesthesia and surgery (“surgery” henceforth) in a cohort of elderly individuals with a subjective cognitive decline ...
Lire la suite >Background We examined the association between preclinical Alzheimer's disease (AD) and undergoing anesthesia and surgery (“surgery” henceforth) in a cohort of elderly individuals with a subjective cognitive decline (SCD). Methods Individuals with SCD (N = 268) were enrolled in a longitudinal follow-up study. Participants underwent comprehensive yearly cognitive evaluation for a period of 4 years. Brain amyloid load and glucose metabolism were studied by 18F-Florbetapir and Fluorodeoxyglucose positron emission tomography (PET) at baseline and after two years of follow-up. Exposure to surgery was systematically assessed during the first two years of follow-up. The association between surgery, cognition and AD markers was evaluated using generalized linear mixed models for cognition and linear models for neuroimaging markers. Results Sixty-five participants (24.25%) underwent surgery during the first year of follow-up, and 43 (16.04%) during the second year. Undergoing surgery had no overall impact on cognition over 4 years of follow-up nor on amyloid load and brain metabolism at two years of follow-up. However, a second step analysis revealed a small but significant association between undergoing surgery and a subtle decline in executive functions such as mental flexibility and divided attention (TMT B-A), in participants with greater amyloid load at baseline (Cohen's f2 = 0.01, multiple comparison corrected p < 0.001). Highly educated participants with surgery had significantly decreased metabolism over two years, when compared to low educated participants (Cohen's f2 = 0.04, p = 0.031). Conclusions Our results suggest that surgery is associated with an increased risk of subtle cognitive decline after surgery, in the cognitively healthy elderly at risk for AD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-22T22:09:51Z
2024-11-06T10:01:36Z