Title :

Assessing the upper motor neuron in amyotrophic lateral sclerosis using the triple stimulation technique: A multicenter prospective study.

Author(s) :

Grapperon, Aude-Marie [Auteur]
Verschueren, Annie [Auteur]
Jouve, Elisabeth [Auteur]
Aix Marseille Université [AMU]
Morizot-Koutlidis, Régine [Auteur]
Lenglet, Timothée [Auteur]
Pradat, Pierre-François [Auteur]
Salachas, François [Auteur]
Bernard, Emilien [Auteur]
Delstanche, Stéphanie [Auteur]
Maertens De Noordhout, Alain [Auteur]
Guy, Nathalie [Auteur]
Danel, Véronique [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Delval, Arnaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Delmont, Emilien [Auteur]
Rolland, Anne-Sophie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Jomir, Laurent [Auteur]
Devos, David [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Wang, François [Auteur]
Attarian, Shahram [Auteur]

Journal title :

Clinical Neurophysiology

Abbreviated title :

Clin Neurophysiol

Volume number :

132

Pages :

2551-2557

Publication date :

2021-10

ISSN :

1872-8952

English keyword(s) :

Amyotrophic lateral sclerosis
Upper motor neuron
Transcranial magnetic stimulation
Triple stimulation technique

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To evaluate the relevance of transcranial magnetic stimulation (TMS) using triple stimulation technique (TST) to assess corticospinal function in amyotrophic lateral sclerosis (ALS) in a large-scale multicenter ...
Show more >Objective To evaluate the relevance of transcranial magnetic stimulation (TMS) using triple stimulation technique (TST) to assess corticospinal function in amyotrophic lateral sclerosis (ALS) in a large-scale multicenter study. Methods Six ALS centers performed TST and conventional TMS in upper limbs in 98 ALS patients during their first visit to the center. Clinical evaluation of patients included the revised ALS Functional Rating Scale (ALSFRS-R) and upper motor neuron (UMN) score. Results TST amplitude ratio was decreased in 62% of patients whereas conventional TMS amplitude ratio was decreased in 25% of patients and central motor conduction time was increased in 16% of patients. TST amplitude ratio was correlated with ALSFRS-R and UMN score. TST amplitude ratio results were not different between the centers. Conclusions TST is a TMS technique applicable in daily clinical practice in ALS centers for the detection of UMN dysfunction, more sensitive than conventional TMS and related to the clinical condition of the patients. Significance This multicenter study shows that TST can be a routine clinical tool to evaluate UMN dysfunction at the diagnostic assessment of ALS patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-06-22T22:17:04Z
2024-11-28T14:42:36Z