Titre :

Juvenile Xanthogranuloma of the Head and Neck: Imaging Findings in 11 Cases

Auteur(s) :

Chalard, François [Auteur]
CHU Trousseau [APHP]
Nguyen, Toan [Auteur]
CHU Trousseau [APHP]
Morel, Baptiste [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Leiber, Louis-Marie [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Roux, Charles-Joris [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Petit, Philippe [Auteur]
Radiologie pédiatrique et prénatale [Hôpital de la Timone - APHM]
Soto-Ares, Gustavo [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Services de neuroradiologie [Lille]
Donadieu, Jean [Auteur]
CHU Trousseau [APHP]
Ducou Le Pointe, Hubert [Auteur]
CHU Trousseau [APHP]

Titre de la revue :

Journal of Pediatric Hematology/Oncology

Nom court de la revue :

J Pediatr Hematol Oncol

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2024-06-10

ISSN :

1536-3678

Mot(s)-clé(s) en anglais :

juvenile Xanthogranuloma
children
head and neck
imaging

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis, occurring mainly in infancy. With an extracutaneous lesion, its diagnosis is difficult, because of a wide clinical spectrum. Here we ...
Lire la suite >Background: Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis, occurring mainly in infancy. With an extracutaneous lesion, its diagnosis is difficult, because of a wide clinical spectrum. Here we demonstrate and characterize imaging features of 11 patients with JXG of the head and neck in various locations. Material and Methods: We recorded clinical data and reviewed all imaging studies of 11 patients with JXG of the head and neck. Ultrasonography (US) alone was performed in 1 patient; MRI alone in 6 patients; US and MRI in 1 patient; and US, CT, and MRI in 3 patients. We evaluated the following characteristics in all studies: location and number of lesions, echogenicity and vascularization on US, density on CT, signal intensity on T1- and T2-weighted images, ADC and enhancement on MRI, and tumor boundaries and bone involvement. Results: Lesions were well-defined in 9 cases, and bone erosion was present in 2. On US, lesions were hypoechoic or hyperechoic and with or without vascularization. On CT, lesions were hyper-dense, with no calcification. On MRI, lesions were mildly hyper-intense or iso-intense on T1-weighted images in 8 of 9 patients, hypo-intense on T2-weighted images in 7 of 10, low ADC in 7 of 9, and enhancement in 7 of 7. Conclusions: The diagnosis of extra cutaneous JXG may be proposed, with the following suggestive criteria: age < 1 year, well-defined lesion, mild hyper-intensity on T1-weighted images, hypo-intensity on T2-weighted images, low ADC, enhancement, and possible adjacent bone involvement.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364

Date de dépôt :

2024-06-26T21:07:07Z
2024-07-05T14:06:55Z