Title :

Impact of age on surgical excision margins for vulvar squamous cell carcinomas: A multicenter study by the francogyn group

Author(s) :

Raimond, E. [Auteur correspondant]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Risques cliniques et sécurité en santé des femmes et en santé périnatale [RISCQ]
Ambroise, C [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Kerbage, Y. [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ouldamer, L [Auteur]
CHU Trousseau [Tours]
Bendifallah, S [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Carcopino, Xavier [Auteur]
Institut méditerranéen de biodiversité et d'écologie marine et continentale [IMBE]
Assistance Publique - Hôpitaux de Marseille [APHM]
Koskas, M. [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
Bolze, P.A. [Auteur]
Ciblage thérapeutique en Oncologie [EA3738]
Lavoué, V. [Auteur]
Oncogenesis, Stress, Signaling [OSS]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Gauthier, T. [Auteur]
CHU Limoges
Graesslin, O. [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Fauconnier, A. [Auteur]
Huchon, C [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]

Journal title :

Surgical Oncology

Pages :

102170

Publisher :

Elsevier

Publication date :

2025

ISSN :

0960-7404

English keyword(s) :

Vulvar cancer
Excision margin
Age

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Introduction: Vulvar cancer is a rare cancer, it most often affects older women, with tumours of more advanced size and stage than in younger patients. The first-line treatment for vulvar cancer is surgery. Current European ...
Show more >Introduction: Vulvar cancer is a rare cancer, it most often affects older women, with tumours of more advanced size and stage than in younger patients. The first-line treatment for vulvar cancer is surgery. Current European and American guidelines recommend negative histological margins. As tumor size is greater in older patients, the aim of this study was to assess the impact of patient age on surgical excision margins in squamous cell carcinomas of the vulva. Material and method: This was a retrospective multicenter observational study. A descriptive analysis of the population was performed and a univariate analysis was performed according to patient age. Survival data were plotted using the Kaplan-Meier method and compared using a log rank test. Survival was analyzed using a Cox model to calculate the Hazard Ratio. Results: Among the 547 patients included, there were 206 patients <65 years and 341 >= 65 years, including 135 >= 80 years. Median postoperative histological lesion size and interquartile range was greater in patients >65 years (30 mm [18-45] versus 26 mm [14-34], p < 0.001). Patients >= 65 years of age more often benefited from radical total vulvectomy (n = 103 (28.8 %) versus n = 44 (20.4 %), p = 0.03). However, negative surgical excision margins were identical between the 2 groups (n = 180 (87.4 %) versus n = 286 (83.9 %), p = 0.21). Revision surgery was performed more frequently in patients <65 years. Recurrence-free survival was better in patients aged <65 years (HR = 0.60; CI95 % (0.45-0.82), p = 0.001). Conclusion: Despite larger tumour size, age is not a factor influencing the achievement of negative excision margins in squamous cell carcinomas of the vulva, at the cost of more radical surgery.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL

Submission date :

2025-01-22T21:25:29Z