Title :

Genetic Factors Altering Immune Responses in Atrial Fibrillation: JACC Review Topic of the Week

Author(s) :

Ninni, Sandro [Auteur]
Institut Pasteur de Lille
Université de Montréal [UdeM]
Montreal Heart Institute - Institut de Cardiologie de Montréal
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Pole Cardio-vasculaire et pulmonaire [CHU Lille]
Dombrowicz, David [Auteur]
Institut Pasteur de Lille
Pole Cardio-vasculaire et pulmonaire [CHU Lille]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
de Winther, Menno [Auteur]
Department of Medical Microbiology and Infection Prevention [Amsterdam]
Amsterdam University Medical Centers [Amsterdam UMC]
Staels, Bart [Auteur]
Institut Pasteur de Lille
Pole Cardio-vasculaire et pulmonaire [CHU Lille]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Montaigne, David [Auteur]
Institut Pasteur de Lille
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nattel, Stanley [Auteur]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
West German Heart Center
University Hospital Essen [AöR]
Université de Montréal [UdeM]
Montreal Heart Institute - Institut de Cardiologie de Montréal

Journal title :

Journal of the American College of Cardiology

Pages :

1163-1176

Publisher :

Elsevier

Publication date :

2024-03

ISSN :

0735-1097

English keyword(s) :

aging
atrial fibrillation
clonal hematopoiesis
epigenomics
genetics
inflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory processes resulting from innate immune ...
Show more >Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory processes resulting from innate immune responses as a cornerstone in AF pathogenesis. Genetic and epigenetic factors affecting leukocytes have been identified as key modulators of the inflammatory response. Inherited variants in genes encoding proteins involved in the innate immune response have been associated with increased risk for AF recurrence and stroke in AF patients. Furthermore, acquired somatic mutations associated with clonal hematopoiesis of indeterminate potential, leukocyte telomere shortening, and epigenetic age acceleration contribute to increased AF risk. In individuals carrying clonal hematopoiesis of indeterminate potential, myocardial monocyte-derived macrophage shift toward a proinflammatory phenotype may precipitate AF. Further studies are needed to better understand the role of genetic regulation of the native immune response in atrial arrhythmogenesis and its therapeutic potential as a target for personalized medicine.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL

Submission date :

2025-01-22T22:51:16Z