Early movement restriction leads to enduring ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Early movement restriction leads to enduring disorders in muscle and locomotion.
Author(s) :
Delcour, Maxime [Auteur]
Neurosciences sensorielles et cognitives [NSC]
Massicotte, Vicky S [Auteur]
Temple University [Philadelphia]
Russier, Michael [Auteur]
Neurosciences sensorielles et cognitives [NSC]
Bras, Helene [Auteur]
Institut de Neurosciences de la Timone [INT]
Peyronnet, Julie [Auteur]
Institut de Neurosciences de la Timone [INT]
Canu, Marie-Helene [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Cayetanot, Florence [Auteur]
Institut de Neurosciences de la Timone [INT]
Barbe, Mary F [Auteur]
Temple University [Philadelphia]
Coq, Jacques-Olivier [Auteur]
Institut de Neurosciences de la Timone [INT]
Neurosciences sensorielles et cognitives [NSC]
Massicotte, Vicky S [Auteur]
Temple University [Philadelphia]
Russier, Michael [Auteur]
Neurosciences sensorielles et cognitives [NSC]
Bras, Helene [Auteur]
Institut de Neurosciences de la Timone [INT]
Peyronnet, Julie [Auteur]
Institut de Neurosciences de la Timone [INT]
Canu, Marie-Helene [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Cayetanot, Florence [Auteur]
Institut de Neurosciences de la Timone [INT]
Barbe, Mary F [Auteur]
Temple University [Philadelphia]
Coq, Jacques-Olivier [Auteur]
Institut de Neurosciences de la Timone [INT]
Journal title :
Brain pathology (Zurich, Switzerland)
Abbreviated title :
Brain Pathol.
Volume number :
28
Pages :
889-901
Publication date :
2018-02-13
ISSN :
1750-3639
English keyword(s) :
musculoskeletal pathologies
treadmill locomotion
cerebral palsy
DCD
disuse
post-activation depression
treadmill locomotion
cerebral palsy
DCD
disuse
post-activation depression
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Motor control and body representation in the central nervous system (CNS) as well as musculoskeletal architecture and physiology are shaped during development by sensorimotor experience and feedback, but the emergence of ...
Show more >Motor control and body representation in the central nervous system (CNS) as well as musculoskeletal architecture and physiology are shaped during development by sensorimotor experience and feedback, but the emergence of locomotor disorders during maturation and their persistence over time remain a matter of debate in the absence of brain damage. By using transient immobilization of the hind limbs, we investigated the enduring impact of postnatal sensorimotor restriction (SMR) on gait and posture on treadmill, age-related changes in locomotion, musculoskeletal histopathology and Hoffmann reflex in adult rats without brain damage. SMR degrades most gait parameters and induces overextended knees and ankles, leading to digitigrade locomotion that resembles equinus. Based on variations in gait parameters, SMR appears to alter age-dependent plasticity of treadmill locomotion. SMR also leads to small but significantly decreased tibial bone length, chondromalacia, degenerative changes in the knee joint, gastrocnemius myofiber atrophy and muscle hyperreflexia, suggestive of spasticity. We showed that reduced and atypical patterns of motor outputs, and somatosensory inputs and feedback to the immature CNS, even in the absence of perinatal brain damage, play a pivotal role in the emergence of movement disorders and musculoskeletal pathologies, and in their persistence over time. Understanding how atypical sensorimotor development likely contributes to these degradations may guide effective rehabilitation treatments in children with either acquired (ie, with brain damage) or developmental (ie, without brain injury) motor disabilities.Show less >
Show more >Motor control and body representation in the central nervous system (CNS) as well as musculoskeletal architecture and physiology are shaped during development by sensorimotor experience and feedback, but the emergence of locomotor disorders during maturation and their persistence over time remain a matter of debate in the absence of brain damage. By using transient immobilization of the hind limbs, we investigated the enduring impact of postnatal sensorimotor restriction (SMR) on gait and posture on treadmill, age-related changes in locomotion, musculoskeletal histopathology and Hoffmann reflex in adult rats without brain damage. SMR degrades most gait parameters and induces overextended knees and ankles, leading to digitigrade locomotion that resembles equinus. Based on variations in gait parameters, SMR appears to alter age-dependent plasticity of treadmill locomotion. SMR also leads to small but significantly decreased tibial bone length, chondromalacia, degenerative changes in the knee joint, gastrocnemius myofiber atrophy and muscle hyperreflexia, suggestive of spasticity. We showed that reduced and atypical patterns of motor outputs, and somatosensory inputs and feedback to the immature CNS, even in the absence of perinatal brain damage, play a pivotal role in the emergence of movement disorders and musculoskeletal pathologies, and in their persistence over time. Understanding how atypical sensorimotor development likely contributes to these degradations may guide effective rehabilitation treatments in children with either acquired (ie, with brain damage) or developmental (ie, without brain injury) motor disabilities.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Univ. Artois
Université de Lille
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2019-09-24T10:01:27Z
2021-02-15T10:24:05Z
2021-06-24T15:53:51Z
2021-06-24T15:56:02Z
2021-09-15T06:16:13Z
2021-09-15T07:51:36Z
2021-09-15T07:54:17Z
2021-02-15T10:24:05Z
2021-06-24T15:53:51Z
2021-06-24T15:56:02Z
2021-09-15T06:16:13Z
2021-09-15T07:51:36Z
2021-09-15T07:54:17Z
Files
- Delcour_et_al-2017-Brain_Pathology.pdf
- Non spécifié
- Confidential access
- Access the document