Title :

Optimization of the formulation of an original hydrogel-based bone cement using a mixture design

Author(s) :

Ly, Océane [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Monchau, Francine [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Rémond, Sébastien [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Lors, Christine [Auteur]
Centre for Materials and Processes [CERI MP - IMT Nord Europe]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]
Jouanneaux, Alain [Auteur]
Institut des Molécules et Matériaux du Mans [IMMM]
Debarre, Étienne [Auteur]
Université d'Artois [UA]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Damidot, Denis [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Nord Europe]

Journal title :

Journal of the Mechanical Behavior of Biomedical Materials

Pages :

103886

Publisher :

Elsevier

Publication date :

2020-10

ISSN :

1751-6161

English keyword(s) :

Mixture design
Bone cement
2-hydroxyethyl methacrylate
Optimization
Mechanical properties
Rheology
Swelling

HAL domain(s) :

Chimie/Matériaux
Chimie/Chimie organique
Chimie/Polymères
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Biotechnologies
Sciences du Vivant [q-bio]/Ingénierie biomédicale
Sciences de l'ingénieur [physics]/Mécanique [physics.med-ph]/Mécanique des matériaux [physics.class-ph]
Statistiques [stat]/Méthodologie [stat.ME]

English abstract : [en]

Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as ...
Show more >Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as foods, cosmetics, and medical devices. Bone cements are used in orthopaedics as a filling biomaterial or as a grout enhancing the embedding of a prosthesis into bone and fixation is achieved by mechanical interlock with metal or bone surfaces. Recently, hydrophilic bone cements have attracted the attention for bone tissue-engineering applications. Here a bone cement containing an acrylic hydrogel (HEMA) as a liquid phase and a blend of corn starch, cellulose acetate and bioceramic filler as a solid phase is investigated by means of a mixture design which is a special topic within statistical Design of Experiments (DoE). Output variables of interest, complex shear modulus, compressive modulus and swelling rate related to rheological, mechanical and swelling properties respectively, are measured for each cement formulation. Applying the mixture design strategy enables to assess the impact of the three powder components on each variable of interest and to determine the optimal formulation in order to achieve the required properties of this HEMA-based bone cement, especially the rheology adapted to the desired clinical application, but also appropriate mechanical and swelling properties.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515

Source :

Harvested from HAL

Submission date :

2025-02-26T10:20:59Z