Title :

A method for MRI-guided bronchoscopy to identify obstructed airway segments

Author(s) :

Mummy, D. G. [Auteur]
Mcintosh, M. J. [Auteur]
Carey, K. J. [Auteur]
Kehoe, S. [Auteur]
Esnault, Stéphane [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Johansson, M. W. [Auteur]
Evans, M. D. [Auteur]
Sorkness, R. L. [Auteur]
Schiebler, M. [Auteur]
Jarjour, N. N. [Auteur]
Denlinger, L. C. [Auteur]
Fain, Sean B. [Auteur]
University of Iowa [Iowa City]

Journal title :

PHYSIOL. REP.

Abbreviated title :

PHYSIOL. REP.

Volume number :

13

Pages :

e70119

Publisher :

The Physiological Society

Publication date :

2025-03-03

ISSN :

2051-817X

English keyword(s) :

asthma
bronchial wall biopsy
bronchoalveolar lavage
CT air trapping
hyperpolarized gas MRI

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Bronchoscopy is not conventionally guided by prior knowledge of segmental airway obstruction. Hyperpolarized gas magnetic resonance imaging (MRI) ventilation abnormalities and computed tomography (CT) air trapping are ...
Show more >Bronchoscopy is not conventionally guided by prior knowledge of segmental airway obstruction. Hyperpolarized gas magnetic resonance imaging (MRI) ventilation abnormalities and computed tomography (CT) air trapping are related to lung function and asthma severity but have not been used to target segmental inflammation and remodeling. We evaluate the feasibility of using bronchoscopy guided by 3He MRI and CT to reveal differences in inflammatory response, morphology, and cellular activity in poorly- (defect) versus well-ventilated (control) lung regions. Eleven participants (5 female; age, 22.8 ± 3.4 years; 9 asthma) who experienced a cold with increased lower airway symptoms underwent 3He MRI and/or CT at least 6 weeks after recovery. Differences between defect and control regions were compared. In defect as compared to control sites, bronchoalveolar lavage neutrophils (p = 0.06) and granulocytes (p = 0.08) trended towards an increase; inflammatory mediators (i.e., 15-epi-LXA4, LXA4) were also significantly different (p < 0.05) between sites. Correlations were observed between macrophages, neutrophils, and eosinophils with inflammatory mediators (i.e., 15-epi-LXA4, LXA4, LTB4). Correlations were observed for macrophages and neutrophils with 15-epi-LXA4, and eosinophils with LXA4 and leukotriene B4. Basement membrane wall thickness was similar for defect versus control sites (p = 0.9). These results support the feasibility of image-guided methods to identify airway obstruction phenotypes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2025-03-06T22:02:42Z
2025-03-19T07:40:45Z