Title :

COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas

Author(s) :

Mohamed, Amal H. [Auteur]
Eltyeb, Ebtihal [Auteur]
Said, Badria [Auteur]
Eltayeb, Raga [Auteur]
Algaissi, Abdullah [Auteur]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Alhazmi, Abdulaziz H. [Auteur]

Journal title :

PeerJ

Abbreviated title :

PeerJ

Volume number :

12

Pages :

e17160

Publisher :

PeerJ

Publication date :

2024-04-18

ISSN :

2167-8359

English keyword(s) :

Mortality
Morbidity
Malaria
COVID-19
Co-infection
Clinical outcome
Infection

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical ...
Show more >Background COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical outcomes of COVID-19 and malaria co-infection to develop effective prevention and treatment strategies. Methods A comprehensive literature search was conducted using MeSH terms and keywords from the start of the COVID-19 pandemic to January 2023. The review included original articles on COVID-19 and malaria co-infection, evaluating their methodological quality and certainty of evidence. It was registered in PROSPERO (CRD42023393562). Results Out of 1,596 screened articles, 19 met the inclusion criteria. These studies involved 2,810 patients, 618 of whom had COVID-19 and malaria co-infection. Plasmodium falciparum and vivax were identified as causative organisms in six studies. Hospital admission ranged from three to 18 days. Nine studies associated co-infection with severe disease, ICU admission, assisted ventilation, and related complications. One study reported 6% ICU admission, and mortality rates of 3%, 9.4%, and 40.4% were observed in four studies. Estimated crude mortality rates were 10.71 and 5.87 per 1,000 person-days for patients with and without concurrent malaria, respectively. Common co-morbidities included Diabetes mellitus, hypertension, cardiovascular diseases, and respiratory disorders. Conclusion Most patients with COVID-19 and malaria co-infection experienced short-term hospitalization and mild to moderate disease severity. However, at presentation, co-morbidities and severe malaria were significantly associated with higher mortality or worse clinical outcomes. These findings emphasize the importance of early detection, prompt treatment, and close monitoring of patients with COVID-19 and malaria co-infection.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2025-03-15T22:07:30Z
2025-03-28T08:26:13Z