New insights on the structure of hexagonally ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and α-cyclodextrin
Auteur(s) :
Ahmed, Zeeshan [Auteur]
Malli, Sophia [Auteur]
Institut Galien Paris-Saclay [IGPS]
Diaz-Salmeron, Raul [Auteur]
Destruel, Pierre-Louis [Auteur]
Da Costa, Antonio [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Guigner, Jean-Michel [Auteur]
Porcher, Florence [Auteur]
Baptiste, Benoit [Auteur]
Ponchel, Gilles [Auteur]
Bouchemal, Kawthar [Auteur]
Malli, Sophia [Auteur]
Institut Galien Paris-Saclay [IGPS]
Diaz-Salmeron, Raul [Auteur]
Destruel, Pierre-Louis [Auteur]
Da Costa, Antonio [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Guigner, Jean-Michel [Auteur]
Porcher, Florence [Auteur]
Baptiste, Benoit [Auteur]
Ponchel, Gilles [Auteur]
Bouchemal, Kawthar [Auteur]
Titre de la revue :
International Journal of Pharmaceutics
Nom court de la revue :
Int J Pharm
Numéro :
548
Pagination :
23-33
Éditeur :
Elsevier
Date de publication :
2018-09-05
Mot(s)-clé(s) en anglais :
Chitosan
Platelets
Self-assembly
α-cyclodextrin
Platelets
Self-assembly
α-cyclodextrin
Discipline(s) HAL :
Chimie
Chimie/Chimie thérapeutique
Chimie/Chimie thérapeutique
Résumé en anglais : [en]
A new class of non-spherical particles was recently designed in our research group by mixing a polysaccharide grafted with fatty acids and α-cyclodextrin in water. Because their flat surfaces, and according to their size, ...
Lire la suite >A new class of non-spherical particles was recently designed in our research group by mixing a polysaccharide grafted with fatty acids and α-cyclodextrin in water. Because their flat surfaces, and according to their size, particles are called micro- or nano-platelets. Here, we varied the composition of fatty acids grafted on chitosan (oleic acid, palmitic acid or stearic acid) and characterized platelet morphology. Transmission electron microscopy (TEM), cryogenic TEM, scanning electron microscopy, atomic force microscopy (AFM) and confocal laser scanning microscopy experiments showed that the platelets have a preferentially hexagonal shape with sharp edges, independently on alkyl chain grafted on chitosan. Furthermore, AFM topographic analysis of platelet surface showed parallel thin terraces with 12–14-nm height, suggesting a multi-layered structure alternating chitosan and fatty-acid/α-cyclodextrin inclusion complexes. We also revealed for the first time that a simple magnetic mixing of fatty acids with α-cyclodextrin in water results from solid inclusion complexes with a crystalline structural organization characterized by powder X-ray diffraction. Our results demonstrate that fatty acid/α-cyclodextrin interaction is the driving force for platelet formation.Lire moins >
Lire la suite >A new class of non-spherical particles was recently designed in our research group by mixing a polysaccharide grafted with fatty acids and α-cyclodextrin in water. Because their flat surfaces, and according to their size, particles are called micro- or nano-platelets. Here, we varied the composition of fatty acids grafted on chitosan (oleic acid, palmitic acid or stearic acid) and characterized platelet morphology. Transmission electron microscopy (TEM), cryogenic TEM, scanning electron microscopy, atomic force microscopy (AFM) and confocal laser scanning microscopy experiments showed that the platelets have a preferentially hexagonal shape with sharp edges, independently on alkyl chain grafted on chitosan. Furthermore, AFM topographic analysis of platelet surface showed parallel thin terraces with 12–14-nm height, suggesting a multi-layered structure alternating chitosan and fatty-acid/α-cyclodextrin inclusion complexes. We also revealed for the first time that a simple magnetic mixing of fatty acids with α-cyclodextrin in water results from solid inclusion complexes with a crystalline structural organization characterized by powder X-ray diffraction. Our results demonstrate that fatty acid/α-cyclodextrin interaction is the driving force for platelet formation.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
ENSCL
CNRS
Centrale Lille
Univ. Artois
Université de Lille
CNRS
Centrale Lille
Univ. Artois
Université de Lille
Collections :
Équipe(s) de recherche :
Couches minces & nanomatériaux (CMNM)
Date de dépôt :
2019-09-25T15:06:54Z
2021-03-04T14:32:55Z
2021-03-04T14:32:55Z