Clinical Impact of Antifungal Susceptibility, ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort
Author(s) :
Gangneux, Jean-Pierre [Auteur]
Institut de recherche en santé, environnement et travail [Irset]
Cornet, Muriel [Auteur]
Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 [TIMC-IMAG]
Bailly, Sebastien [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Feger, Celine [Auteur]
Timsit, Jean-Francois [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Leroy, Olivier [Auteur]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bougnoux, Marie-Elisabeth [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Institut de recherche en santé, environnement et travail [Irset]
Cornet, Muriel [Auteur]
Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 [TIMC-IMAG]
Bailly, Sebastien [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Feger, Celine [Auteur]
Timsit, Jean-Francois [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Leroy, Olivier [Auteur]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bougnoux, Marie-Elisabeth [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Journal title :
Frontiers in Microbiology
Abbreviated title :
Front. Microbiol.
Volume number :
9
Publication date :
2018-12-11
ISSN :
1664-302X
English keyword(s) :
Candida albicans
Candida glabrata
virulence
biofilm
mannoglycoconjugates
oligomannosides
in vitro sensitivity
invasive candidiasis
Candida glabrata
virulence
biofilm
mannoglycoconjugates
oligomannosides
in vitro sensitivity
invasive candidiasis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown.
Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed ...
Show more >Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. Results: Candida albicans was predominant (65.4%, n = 285), with a mortality rate significantly lower than that in patients with non-albicans strains [HR 0.67 (0.46–1.00), p = 0.048]. The rate of fluconazole-resistant strains was low (C. albicans and Candida glabrata: 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among C. albicans (45.4%) than among non-albicans (81.2%). While the strains of C. albicans showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of β-man, which was correlated with an increased mortality (p = 0.02). Conclusion: Candida albicans IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non-albicans strains. A high expression of β-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.Show less >
Show more >Background: The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. Methods: Candida strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. Results: Candida albicans was predominant (65.4%, n = 285), with a mortality rate significantly lower than that in patients with non-albicans strains [HR 0.67 (0.46–1.00), p = 0.048]. The rate of fluconazole-resistant strains was low (C. albicans and Candida glabrata: 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among C. albicans (45.4%) than among non-albicans (81.2%). While the strains of C. albicans showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of β-man, which was correlated with an increased mortality (p = 0.02). Conclusion: Candida albicans IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non-albicans strains. A high expression of β-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2019-10-22T08:16:27Z
2023-12-06T15:18:33Z
2023-12-06T15:18:33Z
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