Cerebral microbleeds: beyond the macroscope

Petrault, Maud; Casolla, Barbara; Ouk, Thavarak; Cordonnier, Charlotte; BEREZOWSKI, Vincent

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1177/1747493019830594

PMID :

30747597

Permalink :

http://hdl.handle.net/20.500.12210/15998

Title :

Cerebral microbleeds: beyond the macroscope

Author(s) :

Petrault, Maud [Auteur]
Casolla, Barbara [Auteur]
Ouk, Thavarak [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Cordonnier, Charlotte [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]

Journal title :

International journal of stroke . official journal of the International Stroke Society

Abbreviated title :

Int J Stroke

Pages :

1747493019830594

Publication date :

2019-02-12

ISSN :

1747-4949

English keyword(s) :

experimental models
intracerebral hemorrhage
cerebral amyloid angiopathy
Cerebral microbleed

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They ...
Show more >While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. While their microscopic size would suggest considering these lesions as anecdotal, they are now regarded as biomarkers of severity of an underlying cerebrovascular disease. Their natural history and the interactions with surrounding brain cells remain unknown. However, their presence may impact therapeutic decisions. Deciphering the biological mechanisms leading to, or following microbleeds would enable us to address a key question: do microbleeds arise and impact the surrounding parenchyma like a miniature version of intracerebral hemorrhages or do they represent a different kind of injury? We hereby discuss, based on both clinical and experimental literature, the gap between the definition of microbleeds coming from neuroimaging and the pathophysiological hypotheses raised from histopathological and experimental data. Our analysis supports the need for a convergent effort from clinicians and basic scientists to go beyond the current "macro" view and disclose the cellular and molecular insights of these cerebral hemorrhagic microlesions.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:03:40Z

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