Bioavailable trace metals in neurological diseases

Poujois, Aurelia; Devedjian, Jean-Christophe; moreau, caroline; DEVOS, DAVID; Chaine, Pascal; Woimant, France; Duce, James A.

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s11940-016-0426-1

PMID :

27682263

URL permanente :

http://hdl.handle.net/20.500.12210/16074

Titre :

Bioavailable trace metals in neurological diseases

Auteur(s) :

Poujois, Aurelia [Auteur]
Devedjian, Jean-Christophe [Auteur]
moreau, caroline [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
DEVOS, DAVID [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Chaine, Pascal [Auteur]
Woimant, France [Auteur]
Duce, James A. [Auteur]

Titre de la revue :

Current treatment options in neurology

Nom court de la revue :

Curr. Treat. Options Neurol.

Numéro :

Date de publication :

2016-10-01

ISSN :

1092-8480

Mot(s)-clé(s) en anglais :

Iron
Copper
Neurodegeneration
Reactive species
Chelation therapy
Manganese

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first ...
Lire la suite >Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first being a de-coppering phase and the second a maintenance one. The best therapeutic approach remains controversial, as only a few non-controlled trials have compared these treatments. During the initial phase, progressive increase of chelators' doses adjusted to exchangeable copper and urinary copper might help to avoid neurological deterioration. Liver transplantation is indicated in acute fulminant liver failure and decompensated cirrhosis; in cases of neurologic deterioration, it must be individually discussed. During the maintenance phase, the most important challenge is to obtain a good adherence to lifelong medical therapy. Neurodegenerative diseases that lead to a mislocalisation of iron can be caused by a culmination of localised overload (pro-oxidant siderosis) and localised deficiency (metabolic distress). A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apo-transferrin, allows iron redistribution to avoid systemic loss of iron.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T13:05:03Z

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