Title :

Off-label prescribing of antipsychotics in adults, children and elderly individuals: a systematic review of recent prescription trends

Author(s) :

Carton, Louise [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Cottencin, Olivier [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Lapeyre-Mestre, Maryse [Auteur]
Geoffroy, Pierre-Alexis [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Favre, Jonathan [Auteur]
Simon, Nicolas [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Rolland, Benjamin [Auteur]

Journal title :

Current Pharmaceutical Design

Abbreviated title :

Curr. Pharm. Design

Volume number :

21

Pages :

3280-3297

Publication date :

2015-01-01

ISSN :

1381-6128

English keyword(s) :

children
pharmacoepidemiology
Adults
safety
elderly
off-label
antipsychotics
Mesh:Mental Disorders/psychology
Mesh:Mental Disorders/drug therapy*
Mesh:Mental Disorders/diagnosis
Mesh:Inappropriate Prescribing/trends
Mesh:Humans
Mesh:Drug Prescriptions
Mesh:Child
Mesh:Treatment Outcome
Mesh:Young Adult
Mesh:Risk Factors
Mesh:Risk Assessment
Mesh:Practice Patterns
Mesh:Physicians''/trends*
Mesh:Patient Safety
Mesh:Antipsychotic Agents/therapeutic use*
Mesh:Antipsychotic Agents/adverse effects
Mesh:Aged
Mesh:Age Factors
Mesh:Adult
Mesh:Adolescent
Mesh:Off-Label Use*
Mesh:Middle Aged

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences cognitives

English abstract : [en]

BACKGROUND: New antipsychotics continuously arrive on the market, which thereby influences the approved and off-label prescribing (OLP) schemes. We aimed to identify the recent trends in the OLP of antipsychotics. We ...
Show more >BACKGROUND: New antipsychotics continuously arrive on the market, which thereby influences the approved and off-label prescribing (OLP) schemes. We aimed to identify the recent trends in the OLP of antipsychotics. We conducted a literature review based on three different populations: adult, pediatric, and elderly patients. METHODS: A literature search was performed in the PubMed and ScienceDirect databases using the following keyword algorithm: "offlabel" AND ("antipsychotic*" OR "neuroleptic*"). The period investigated ranged from January 2000 to January 2015. Only Englishwritten pharmacoepidemiological studies were included. RESULTS: Seventy-seven relevant results were identified. Among adults, OLP consisted of 40 to 75% of all antipsychotic prescriptions. The main indications were mood disorders, anxiety disorders, insomnia and agitation. Quetiapine was the most frequently prescribed offlabel antipsychotic, especially for anxiety and insomnia. Among children, OLP was estimated between 36 and 93.2% of all antipsychotic prescriptions. Risperidone and aripiprazole were primarily used and were most often prescribed for attention deficit hyperactivity disorder, anxiety, or mood disorders. Among elderly individuals, OLP consisted of 22 to 86% of all antipsychotic prescriptions. Antipsychotic OLP was particularly frequent for agitation; however, a recent decrease in this OLP was identified. CONCLUSIONS: Antipsychotics have largely been prescribed off-label in recent years. The types of antipsychotic OLP practices differ according to the age category of patients. OLP is often used in cases of therapeutic dead-ends or for specific disorders with few or no currently approved medications. However, other OLP practices only reflect temporary prescription trends for mild symptoms, which may induce safety concerns.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:33:35Z
2020-04-06T09:50:00Z