Title :

Cholinergic modulation of stimulus-driven attentional capture

Author(s) :

Boucart, Muriel [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Michael, George Andrew [Auteur]
Bubicco, Giovanna [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Ponchel, Amélie [Auteur]
Waucquier, Nawal [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Deguil, Julie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]

Journal title :

Behavioural brain research

Abbreviated title :

Behav. Brain Res.

Volume number :

283

Pages :

47-52

Publication date :

2015-04-15

ISSN :

0166-4328

English keyword(s) :

Acetylcholine
Donepezil
Attentional capture
Visual attention
Superior colliculus
Mesh:Cholinesterase Inhibitors/pharmacology*
Mesh:Cross-Over Studies
Mesh:Double-Blind Method
Mesh:Humans
Mesh:Indans/pharmacology*
Mesh:Male
Mesh:Neuropsychological Tests
Mesh:Nootropic Agents/pharmacology*
Mesh:Photic Stimulation
Mesh:Piperidines/pharmacology*
Mesh:Reaction Time
Mesh:Visual Perception/drug effects*
Mesh:Visual Perception/physiology
Mesh:Young Adult
Mesh:Adult
Mesh:Attention/drug effects*
Mesh:Attention/physiology

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences cognitives

English abstract : [en]

Distraction is one of the main problems encountered by people with degenerative diseases that are associated with reduced cortical cholinergic innervations. We examined the effects of donepezil, a cholinesterase inhibitor, ...
Show more >Distraction is one of the main problems encountered by people with degenerative diseases that are associated with reduced cortical cholinergic innervations. We examined the effects of donepezil, a cholinesterase inhibitor, on stimulus-driven attentional capture. Reflexive attention shifts to a distractor are usually elicited by abrupt peripheral changes. This bottom-up shift of attention to a salient item is thought to be the result of relatively inflexible hardwired mechanisms. Thirty young male participants were randomly allocated to one of two groups: placebo first/donepezil second session or the opposite. They were asked to locate a target appearing above and below fixation whilst a peripheral distractor moved abruptly (motion-jitter attentional capture condition) or not (baseline condition). A classical attentional capture effect was observed under placebo: moving distractors interfered with the task in slowing down response times as compared to the baseline condition with fixed distractors. Increased interference from moving distractors was found under donepezil. We suggest that attentional capture in our paradigm likely involved low level mechanisms such as automatic reflexive orienting. Peripheral motion-jitter elicited a rapid reflexive orienting response initiated by a cholinergic signal from the brainstem pedunculo-pontine nucleus that activates nicotinic receptors in the superior colliculus.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:33:38Z
2019-12-03T15:55:17Z