Titre :

Bullous pemphigoid induced by vildagliptin: a report of three cases

Auteur(s) :

Bene, Johana [Auteur]
Jacobsoone, Aurelie [Auteur]
Coupe, Patrick [Auteur]
Auffret, Marine [Auteur]
Babai, Samy [Auteur]
Hillaire-Buys, Dominique [Auteur]
Jean-Pastor, Marie-Josephe [Auteur]
Vonarx, Marlene [Auteur]
Vermersch, Annie [Auteur]
Tronquoy, Anne-Fleur [Auteur]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171

Titre de la revue :

Fundamental & clinical pharmacology

Nom court de la revue :

Fundam. Clin. Pharmacol.

Numéro :

29

Pagination :

112-114

Date de publication :

2015-02-01

ISSN :

0767-3981

Mot(s)-clé(s) en anglais :

gliptins
bullous pemphigoid
adverse reactions
drug-induced skin disorder

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86-year-old woman presented with bullous pemphigoid after 1 month of treatment with vildagliptin and metformin. After introduction ...
Lire la suite >To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86-year-old woman presented with bullous pemphigoid after 1 month of treatment with vildagliptin and metformin. After introduction of clobetasol, the symptoms resolved although vildagliptin was continued. However, the skin lesions reappeared 3 months later. Sustained remission was achieved only after definitive withdrawal of vildagliptin. Case 2: A 79-year-old man presented with bullous pemphigoid after 37-month treatment with gliclazide, vildagliptin and metformin. The disease at first responded to clobetasol but 3 months later the lesions reappeared. They finally regressed when the gliptin was discontinued. Case 3: A 77-year-old woman, treated with gliclazide and vildagliptin for 26 months, presented with bullous pemphigoid, which responded well to discontinuation of the gliptin and topical clobetasol. Gliptins are new molecules for treatment of type 2 diabetes mellitus, which have been suspected of implication in bullous pemphigoid. Such cases have been described in the literature (seven with vildagliptin and three with sitagliptin). In nine of these cases, the gliptin was associated with metformin, but the latter had never been considered responsible. The mechanism implicated in the development of bullous pemphigoid has not yet been clearly identified, but may involve a modified immune response or alteration of the antigenic properties of the epidermal basement membrane. These reports support the risk of bullous pemphigoid in patients exposed to gliptins.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T13:36:20Z