Title :

Reduced basal forebrain atrophy progression in a randomized donepezil trial in prodromal alzheimer's disease

Author(s) :

Cavedo, Enrica [Auteur]
Grothe, Michel J. [Auteur]
Colliot, Olivier [Auteur]
Lista, Simone [Auteur]
Chupin, Marie [Auteur]
Dormont, Didier [Auteur]
Houot, Marion [Auteur]
Lehericy, Stéphane [Auteur]
Teipel, Stefan J. [Auteur]
Dubois, Bruno [Auteur]
Hampel, Harald [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Delmaire, Christine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Scientific Reports

Abbreviated title :

Sci Rep

Volume number :

7

Pages :

11706

Publication date :

2017-09-15

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Acetylcholinesterase inhibitors are approved drugs currently used for the treatment of Alzheimer's disease (AD) dementia. Basal forebrain cholinergic system (BFCS) atrophy is reported to precede both entorhinal cortex ...
Show more >Acetylcholinesterase inhibitors are approved drugs currently used for the treatment of Alzheimer's disease (AD) dementia. Basal forebrain cholinergic system (BFCS) atrophy is reported to precede both entorhinal cortex atrophy and memory impairment in AD, challenging the traditional model of the temporal sequence of topographical pathology associated with AD. We studied the effect of one-year Donepezil treatment on the rate of BFCS atrophy in prodromal AD patients using a double-blind, randomized, placebo-controlled trial of Donepezil (10 mg/day). Reduced annual BFCS rates of atrophy were found in the Donepezil group compared to the Placebo treated arm. Secondary analyses on BFCS subregions demonstrated the largest treatment effects in the Nucleus Basalis of Meynert (NbM) and the medial septum/diagonal band (Ch1/2). Donepezil administered at a prodromal stage of AD seems to substantially reduce the rate of atrophy of the BFCS nuclei with highest concentration of cholinergic neurons projecting to the cortex (NbM), hippocampus and entorhinal cortex (Ch1/2).Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Autres travaux scientifiques

Submission date :

2019-11-27T13:36:44Z
2021-05-17T08:18:12Z
2021-08-30T13:23:34Z
2024-01-10T14:57:57Z