Title :

Daphne: a new tool for the assessment of the behavioral variant of frontotemporal dementia

Author(s) :

Boutoleau-Bretonniere, Claire [Auteur]
Evrard, Christelle [Auteur]
Hardouin, Jean Benoit [Auteur]
Rocher, Laetitia [Auteur]
Charriau, Tiphaine [Auteur]
Etcharry-Bouyx, Frederique [Auteur]
Auriacombe, Sophie [Auteur]
Richard-Mornas, Aurelie [Auteur]
Lebert, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Sauvaget, Anne [Auteur]
Bulteau, Samuel [Auteur]
Vercelletto, Martine [Auteur]
Derkinderen, Pascal [Auteur]
Bretonniere, Cedric [Auteur]
Thomas-Anterion, Catherine [Auteur]

Journal title :

Dementia and Geriatric Cognitive Disorders Extra

Abbreviated title :

Dement Geriatr Cogn Dis Extra

Volume number :

5

Pages :

503-16

Publication date :

2015-01-01

ISSN :

1664-5464

English keyword(s) :

Progressive supranuclear palsy
Alzheimer''s disease
Behavioral disorders
Frontotemporal dementia
Scale
Bipolar disorder

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, ...
Show more >BACKGROUND: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, justifying development of new clinical tools. OBJECTIVE: We produced a behavioral inventory named DAPHNE. This scale (adapted from Rascovsky's criteria) explores six domains: disinhibition, apathy, perseverations, hyperorality, personal neglect and loss of empathy. It is composed of ten items (five answer categories). The aim was (1) to assess the validity and reliability of DAPHNE and (2) to evaluate its contribution in differentiating patients. METHODS: Two scores were computed: DAPHNE-6 (screening) from the six domains and DAPHNE-40 (diagnosis) from the ten items. Reliability and reproducibility were assessed. External validity was studied with the Frontal Behavioral Inventory (FBI) and the Frontotemporal Behavioral Scale (FBS). Finally, the diagnostic performance of DAPHNE was compared to revised criteria, FBI and FBS. RESULTS: DAPHNE was administered to the caregivers of 89 patients, 36 with bvFTD, 22 with Alzheimer's disease, 15 with progressive supranuclear palsy and 16 with bipolar disorder. Reliability and reproducibility were excellent, as was external validity. DAPHNE-6 allowed bvFTD diagnosis (score ≥4) with a sensitivity of 92%, while DAPHNE-40 (score ≥15) had a specificity of 92%. CONCLUSIONS: We demonstrate excellent psychometric features for DAPHNE. This quick tool could help for both diagnosing and screening bvFTD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:28:45Z